Protein Alignment nAChRalpha1 and LOC4578226

DIOPT Version :10

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: XP_061513968.1
• Gene: LOC4578226 / 4578226
• VectorBaseID: AGAMI1_011717
• Length: 439
• Species: Anopheles gambiae
• Alignment Length: 399
• Identity: 93/399 - (23%)
• Similarity: 153/399 - (38%)
• Gaps: 75/399 - (18%)

  Fly     6 FAAVFIALHFATGGLANPDAK------RLYDDLL-SNYNRLIRPVGNNSDRLTVKMGLRLSQLID 63
            |..:| .:|.|..  .|.||:      ||...|. ::|::..|||.::.....|.:.:.:.....
Mosquito    11 FLTIF-KIHCAVA--FNCDAEQSSIEGRLQKQLFCTDYDKSQRPVEHHETATNVSISIYMKNYAL 72

  Fly    64 VNLKNQIMTTNVWVEQEWNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMT- 127
            ......:..:| |:...|.|..|.|:..|| |:|.|:|....||.|.|..|:....|   ||..
Mosquito    73 YEYDPSLHISN-WLSVSWKDEFLTWDRADY-GIDMLNVDESEIWRPMITSYSKKQLN---TIDRS 132

  Fly   128 ----KAILHHTGKVVWKPPAIYKSFC---EIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQT 185
                |..|.|||:|....|..|::.|   .||   :|||...|.:.|.||..  |..:|    ..
Mosquito   133 CNDHKCELKHTGEVSCISPCTYEAHCTSTNID---WPFDVMDCRLYFSSWLQ--YKSEL----NM 188

  Fly   186 ADSDNIEVGIDLQDYYISVEWDIMRVPAVRNEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIP 250
            ..:.|:.......::|   .|.::   :...|......::.|..:|:.....|....||. ::.|
Mosquito   189 TGASNVSTSYVTHNHY---SWKLL---SAEKENSNHSDDDTYPSVVYVFKFERHMGLYTA-ILTP 246

  Fly   251 CVGISFLSVLVFYLPSDSGEKISLCISILLSLTVFFLLL-------AEIIPPTSLTVPLLGKYLL 308
            ...:..||.||.:|...|.|::.:..:..:....|...|       .|.:|          |.||
Mosquito   247 GFLLVVLSWLVLWLDYSSSERLYILYATCIGHFTFMEFLFWHQSHQTEDVP----------KMLL 301

  Fly   309 FTMMLVTLSVVVTIAVLNVNFRSPVTHRMAP------WVQRLFIQILPKLLCIE----------- 356
            |....:.::|...|..:.:.:.:|..|  :|      |..|:....|.::|.:.
Mosquito   302 FYRDSLFINVFTVILTIILKYTNPKPH--SPERLIDRWAFRVASTSLGRVLLLRGHFIGSKRTLL 364

  Fly   357 RPKKEEPEE 365
            |.:.||.:|
Mosquito   365 REENEEGKE 373

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	LGIC_ECD_nAChR_proto_alpha-like	24..242	CDD:349832	57/232 (25%)
		LIC	27..530	CDD:455710	86/372 (23%)
		Cys-loop	149..163	CDD:349832	6/16 (38%)
LOC4578226	XP_061513968.1	None