Protein Alignment nAChRalpha1 and pHCl-2

DIOPT Version :9

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_001303470.1
• Gene: pHCl-2 / 43703
• FlyBaseID: FBgn0039840
• Length: 526
• Species: Drosophila melanogaster
• Alignment Length: 341
• Identity: 77/341 - (22%)
• Similarity: 143/341 - (41%)
• Gaps: 69/341 - (20%)

  Fly    20 LANPDAKRLYDDLLS------NYNRLIRPVGNNSDRLTVKMGL--RLSQLIDVNLKNQIM--TTN 74
            |.|.::..|. :||:      .|:|::.||.:|.|...|.|.:  |....:..||.:..:  |..
  Fly    64 LKNAESMALM-ELLTRLTAPCRYDRMVPPVVHNKDGEEVPMDIYARFYIYVMKNLDSSDLQFTVQ 127

  Fly    75 VWVEQEWNDYKLKWNPDDYGGVDTLHVPSEH------------IWLPDIVLYNNADGNYEVTIMT 127
            ..::..:.|.:|.::.         ::|:..            :|:|.|.|.|.   .....:.|
  Fly   128 GLLQLRYLDPRLAFSS---------YLPNRRQPIMGESELKKMLWVPHIFLTNE---QASTVLGT 180

  Fly   128 KA-----ILHHTGKVVWKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTAD 187
            .|     .::..|.|:.........:|.::.:.||||||.|.....||.|:..:|.|..  :|.:
  Fly   181 SAKDELTSIYPNGTVLTSTRLQATLYCWMNFQKFPFDEQKCKTTLESWMYNTTLVQLHW--ETDN 243

  Fly   188 SDNIEVGIDLQDYYI--SVEWDIMRVPAVRNEKFYS--CCEEPYLDIVFNLTLRRKTLFYTVNLI 248
            ..:.:..:.|.:|.:  |:..:.:|   |.||.:.|  ..|..|..|.|.:.|.|:..:|.::..
  Fly   244 PVSFDKQLQLTEYNLIGSLYNESIR---VSNESYMSHGSLEGNYSIISFTVLLTREVGYYVIDYF 305

  Fly   249 IPCVGISFLSVLVFYLPSD-SGEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMM 312
            :|.:.|..:|.:.|:|.:| :..:.:|..:.|||.               :|:.|..:..|..:.
  Fly   306 LPSIMIVTISWVSFWLQADQTPARTTLGCTTLLSF---------------ITLSLSQENNLMKVS 355

  Fly   313 LVTLS----VVVTIAV 324
            .||:|    :|.||.:
  Fly   356 YVTMSEVWFLVCTIFI 371

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	Neur_chan_LBD	25..240	CDD:280998	55/245 (22%)
		LIC	27..530	CDD:273305	75/334 (22%)
		Neur_chan_memb	247..530	CDD:280999	19/83 (23%)
pHCl-2	NP_001303470.1	LIC	46..522	CDD:273305	77/341 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447288
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18945
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030