DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha1 and nAChRbeta2

DIOPT Version :9

Sequence 1:	NP_001262916.1	Gene:	nAChRalpha1 / 42918	FlyBaseID:	FBgn0000036	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	NP_524483.1	Gene:	nAChRbeta2 / 42920	FlyBaseID:	FBgn0004118	Length:	519	Species:	Drosophila melanogaster

Alignment Length:	556	Identity:	302/556 - (54%)
Similarity:	390/556 - (70%)	Gaps:	59/556 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SVLFAAVFIALHFATGGL---ANPDAKRLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDV 64
            |:|...:.:.|..:|..:   ||||.||||||||||||||||||.||::.|||.:||:|||||:|
  Fly     5 SLLCVFLLVPLANSTAPISFEANPDTKRLYDDLLSNYNRLIRPVVNNTETLTVWLGLKLSQLIEV 69

  Fly    65 NLKNQIMTTNVWVEQEWNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKA 129
            |||||:||||:||:|.|.||||:|:|::||||:.|:|||||||:||||||||.|||||||:||||
  Fly    70 NLKNQVMTTNLWVKQRWFDYKLRWDPEEYGGVEQLYVPSEHIWVPDIVLYNNWDGNYEVTLMTKA 134

  Fly   130 ILHHTGKVVWKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEVG 194
            .|.:||:|.|:|||||||.||::|||||:|||.||||||||||:|..|||:||.|...|:.::||
  Fly   135 TLKYTGEVFWEPPAIYKSSCEMNVEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSNLVQVG 199

  Fly   195 IDLQDYYISVEWDIMRVPAVRNEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSV 259
            |||.::|:||||||:.|||.:||::|....||:.||.|.||:||||||||||||:|||.::||:|
  Fly   200 IDLTEFYLSVEWDILEVPATKNEEYYPDTLEPFSDITFKLTMRRKTLFYTVNLIVPCVALTFLTV 264

  Fly   260 LVFYLPSDSGEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAV 324
            ||||||||||||::||||||:||||||||||||||||||.||||||||||||:||:|||..|:.|
  Fly   265 LVFYLPSDSGEKVTLCISILVSLTVFFLLLAEIIPPTSLAVPLLGKYLLFTMILVSLSVWTTVCV 329

  Fly   325 LNVNFRSPVTHRMAPWVQRLFIQILPKLLCIERPKKEEPEEDQPPEVLTDVYHLPPDVDKFVNYD 389
            ||::||||.||.|:|.|::||:..:|||:.:.|.:                |.||       :||
  Fly   330 LNIHFRSPSTHNMSPLVRKLFLHFMPKLMMMRRTQ----------------YTLP-------DYD 371

  Fly   390 SKRFSGDYGIPALPASHRFDLAAAGGISAHCFAEPPLPSSLPLPGADDDLFSPSGLNGDISPGCC 454
            ....|..|       ::..|:..:       .::.|........||.|:....|..:.::.|
  Fly   372 DSTPSNGY-------TNEIDVRDS-------ISDFPSEFKDSQDGAYDNGMQNSVDSDNVIP--- 419

  Fly   455 PAAAAAAAADLSPTFEKPYAREMEKTIEGSRFIAQHVKNKDKFESVEEDWKYVAMVLDRMFLWIF 519
                    .:|:|        |:.:.:...||||||:|:.||...:.||||:|:|||||.|||:|
  Fly   420 --------RNLTP--------EVLQALRAVRFIAQHIKDADKDNEIVEDWKFVSMVLDRFFLWLF 468

  Fly   520 AIACVVGTALIILQAPSLYDQSQPIDILYSKIAKKK 555
            .::||.||..||.|:|||||...|||...|:|..:|
  Fly   469 TLSCVFGTLAIICQSPSLYDTRSPIDRQLSEIPLRK 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	Neur_chan_LBD	25..240	CDD:280998	148/214 (69%)
		LIC	27..530	CDD:273305	279/502 (56%)
		Neur_chan_memb	247..530	CDD:280999	124/282 (44%)
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:273305	286/525 (54%)
nAChRbeta2	NP_524483.1	LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	151/217 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447351
Domainoid	1	1.000	250	1.000	Domainoid score	I2065
eggNOG	1	0.900	-	-		E1_KOG3645
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	473	1.000	Inparanoid score	I1461
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	1	1.000	-	-		FOG0000583
OrthoInspector	1	1.000	-	-		mtm6399
orthoMCL	1	0.900	-	-		OOG6_101158
Panther	1	1.100	-	-	P	PTHR18945
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2381
SonicParanoid	1	1.000	-	-		X294
	12	11.830