Protein Alignment nAChRalpha1 and lgc-29

DIOPT Version :9

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_001317792.1
• Gene: lgc-29 / 3896858
• WormBaseID: WBGene00044528
• Length: 398
• Species: Caenorhabditis elegans
• Alignment Length: 420
• Identity: 89/420 - (21%)
• Similarity: 165/420 - (39%)
• Gaps: 124/420 - (29%)

  Fly    27 RLYDDLLSNYNRLIR--------PVGNNS---DRLTVKMGLRLSQLIDVNLKNQIMTTNVWVEQE 80
            ||::.|..:|:..|.        |..|.:   .|..:.:.|.:.:|::|....:..|.......:
 Worm    40 RLFEKLFKSYDPGINAIYTLHSVPETNGTVHPPRFEITIQLSMMKLVEVVEPEEKATFLFDYRAD 104

  Fly    81 WNDYKLKWNPDDYGGVDTLHVPSEHIWLP----------DIVLYNNADGNYEVTIMTKAILHHTG 135
            |.|.:|.|:|:||||::.::||...:|:|          :|.:::|....|       |.||..|
 Worm   105 WYDTRLSWDPEDYGGINHIYVPRSKVWIPETTIVDCFSSEIKVFDNEYTRY-------AWLHSNG 162

  Fly   136 KVVWKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEVGIDLQDY 200
            .:.....::....|::||..||.|..||.:.|...||                       .|:::
 Worm   163 SIGMYIASVTSVVCQMDVYKFPMDTHTCSVNFLFMTY-----------------------QLEEF 204

  Fly   201 YI---------------SVEWDIMRVPAVRNEKFYSCCEEPYLDIV-----FNLTLRRKTLFYTV 245
            .|               :.||.:         |......||.:|.:     |..|..|...||.|
 Worm   205 TIVGKTGTLPRPVEQLGNGEWQM---------KSIQIAFEPVVDNLTYLTKFEATFSRNPGFYIV 260

  Fly   246 NLIIPCVGISFLSVLVFYLP-SDSGEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLF 309
            .::||...|:.||::..::. ::..||.::.::.::|::...::|||.:|.|. .:|:|..|.:.
 Worm   261 LVMIPAYFINVLSIVALFMDINNRSEKFTVGMTNIMSMSFILVILAEDLPKTK-NLPILAIYTVT 324

  Fly   310 TMMLVTLSVVVTIAVLNVNFRSPVTHRMAPWVQRLFIQILPKLLC------IERPKKEEPEEDQP 368
            ::.::..|:...:|                         ||||..      :.|.:| .|:.|:.
 Worm   325 SLAIMLCSLTAVVA-------------------------LPKLKAYYANRSLARGEK-IPKNDEV 363

  Fly   369 PEVLTD----------VYHLPPDVDKFVNY 388
            |....:          |:.|...:..|||:
 Worm   364 PRTFWERIKFYFKVEYVFMLVFQIANFVNF 393

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	Neur_chan_LBD	25..240	CDD:280998	54/253 (21%)
		LIC	27..530	CDD:273305	89/420 (21%)
		Neur_chan_memb	247..530	CDD:280999	32/159 (20%)
lgc-29	NP_001317792.1	LIC	38..>337	CDD:273305	74/336 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810