DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha1 and acr-25

DIOPT Version :9

Sequence 1:	NP_001262916.1	Gene:	nAChRalpha1 / 42918	FlyBaseID:	FBgn0000036	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	NP_001023570.2	Gene:	acr-25 / 3565563	WormBaseID:	WBGene00043066	Length:	544	Species:	Caenorhabditis elegans

Alignment Length:	566	Identity:	180/566 - (31%)
Similarity:	283/566 - (50%)	Gaps:	64/566 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LFAAVFIALHFATGGLANPDAKRLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLKNQ 69
            |...:.:.|.....|:.......||.:||.:|..|.||:.|:|:.:.|||||.|.|::||:.|||
Worm     6 LILKLCLLLALGRNGITQKSEGDLYTELLEDYEPLERPIENSSEAVMVKMGLVLQQIVDVDEKNQ 70

  Fly    70 IMTTNVWVEQEWNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKAILHHT 134
            ::..|.|::..|.||.|||.|:|||||..|......:|.||:::||:||..::....:..:::..
Worm    71 VVDVNAWLKFSWVDYSLKWKPEDYGGVTDLRFRKGQLWTPDVLMYNSADPQFDSRYASNLLVYPN 135

  Fly   135 GKVVWKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEVGIDLQD 199
            |.|.|.||.:|:..|:|.|.:||||.|.||:||||||:||..::|.      ..||   |.|:.:
Worm   136 GLVNWMPPGLYRLSCKIQVVWFPFDVQECFLKFGSWTFDGTKLNLE------IDDN---GFDISN 191

  Fly   200 YYISVEWDIMRVPAVRNEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSVLVFYL 264
            |..:.||.:......||.::|.||.|||.|:||...:||:.|:|..|||:||:.|:.|:::.|..
Worm   192 YMQNGEWTLEGTTVKRNIQYYQCCPEPYYDLVFTFVIRRRALYYAFNLILPCILITMLTLVGFTF 256

  Fly   265 PSDSGEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAVLNVNF 329
            |.|:|||:||.|:|:||:.:|...:||:.||||..||.|..:  |.:.|.|.:..||...|.:||
Worm   257 PPDAGEKMSLQITIMLSICIFQNYVAELSPPTSEAVPFLSAF--FAVCLFTCACCVTATTLALNF 319

  Fly   330 --RSPVTHRMAPWVQRLFIQILPKLLCIERP---------KKEEPEEDQPPEVLT--DVYHLPPD 381
              |:..:|:|....:.|.::.:|.||.:.||         .|::..||:..|..|  |...:...
Worm   320 HHRTGKSHQMNNTFRLLMLEWIPWLLMMRRPGYVARCGKIVKQDDSEDEFEERQTRLDQQRIATI 384

  Fly   382 VDKFVNYDSKRFSGDYGIPALPASHRFDLAAAGGISAHCFAEPPLPSSLPLPGADDDLFSPSGLN 446
            :.:.....:|      ..|..|..    :.....:::...||.|||....:...|||:.|...
Worm   385 ISQITVESNK------PTPTFPRR----VTIVDEVNSDGEAEEPLPPDEVIREEDDDVASMDD-- 437

  Fly   447 GDISPGCCPAAAAAAAADLSPTFEKPYAREMEKTIEGSRF----IAQ----------------HV 491
                    |.|..:......|.....:.........|:|.    |||                |:
Worm   438 --------PPAWRSTTTTSQPPQSPAHLWWNATNRMGNRVPVEQIAQLLVLQQVHGHLSEINKHI 494

  Fly   492 KNKDKFESVEEDWKYVAMVLDRMFLWIFAIACVVGTALIILQAPSL 537
            :.::|.:.:|:|||:.|:|:||:.:.||.......|..:....|::
Worm   495 REREKSKKIEDDWKFSALVVDRICMVIFTSFLFGSTVALFASVPNI 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	Neur_chan_LBD	25..240	CDD:280998	89/214 (42%)
		LIC	27..530	CDD:273305	176/535 (33%)
		Neur_chan_memb	247..530	CDD:280999	84/315 (27%)
acr-25	NP_001023570.2	Neur_chan_LBD	26..231	CDD:280998	88/213 (41%)
acr-25	NP_001023570.2	Neur_chan_memb	239..534	CDD:280999	84/316 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910