DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRalpha1 and acr-25

DIOPT Version :10

Sequence 1:NP_001262916.1 Gene:nAChRalpha1 / 42918 FlyBaseID:FBgn0000036 Length:597 Species:Drosophila melanogaster
Sequence 2:NP_001023570.2 Gene:acr-25 / 3565563 WormBaseID:WBGene00043066 Length:544 Species:Caenorhabditis elegans


Alignment Length:566 Identity:180/566 - (31%)
Similarity:283/566 - (50%) Gaps:64/566 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 LFAAVFIALHFATGGLANPDAKRLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLKNQ 69
            |...:.:.|.....|:.......||.:||.:|..|.||:.|:|:.:.|||||.|.|::||:.|||
 Worm     6 LILKLCLLLALGRNGITQKSEGDLYTELLEDYEPLERPIENSSEAVMVKMGLVLQQIVDVDEKNQ 70

  Fly    70 IMTTNVWVEQEWNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKAILHHT 134
            ::..|.|::..|.||.|||.|:|||||..|......:|.||:::||:||..::....:..:::..
 Worm    71 VVDVNAWLKFSWVDYSLKWKPEDYGGVTDLRFRKGQLWTPDVLMYNSADPQFDSRYASNLLVYPN 135

  Fly   135 GKVVWKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEVGIDLQD 199
            |.|.|.||.:|:..|:|.|.:||||.|.||:||||||:||..::|.      ..||   |.|:.:
 Worm   136 GLVNWMPPGLYRLSCKIQVVWFPFDVQECFLKFGSWTFDGTKLNLE------IDDN---GFDISN 191

  Fly   200 YYISVEWDIMRVPAVRNEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSVLVFYL 264
            |..:.||.:......||.::|.||.|||.|:||...:||:.|:|..|||:||:.|:.|:::.|..
 Worm   192 YMQNGEWTLEGTTVKRNIQYYQCCPEPYYDLVFTFVIRRRALYYAFNLILPCILITMLTLVGFTF 256

  Fly   265 PSDSGEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAVLNVNF 329
            |.|:|||:||.|:|:||:.:|...:||:.||||..||.|..:  |.:.|.|.:..||...|.:||
 Worm   257 PPDAGEKMSLQITIMLSICIFQNYVAELSPPTSEAVPFLSAF--FAVCLFTCACCVTATTLALNF 319

  Fly   330 --RSPVTHRMAPWVQRLFIQILPKLLCIERP---------KKEEPEEDQPPEVLT--DVYHLPPD 381
              |:..:|:|....:.|.::.:|.||.:.||         .|::..||:..|..|  |...:...
 Worm   320 HHRTGKSHQMNNTFRLLMLEWIPWLLMMRRPGYVARCGKIVKQDDSEDEFEERQTRLDQQRIATI 384

  Fly   382 VDKFVNYDSKRFSGDYGIPALPASHRFDLAAAGGISAHCFAEPPLPSSLPLPGADDDLFSPSGLN 446
            :.:.....:|      ..|..|..    :.....:::...||.|||....:...|||:.|...  
 Worm   385 ISQITVESNK------PTPTFPRR----VTIVDEVNSDGEAEEPLPPDEVIREEDDDVASMDD-- 437

  Fly   447 GDISPGCCPAAAAAAAADLSPTFEKPYAREMEKTIEGSRF----IAQ----------------HV 491
                    |.|..:......|.....:.........|:|.    |||                |:
 Worm   438 --------PPAWRSTTTTSQPPQSPAHLWWNATNRMGNRVPVEQIAQLLVLQQVHGHLSEINKHI 494

  Fly   492 KNKDKFESVEEDWKYVAMVLDRMFLWIFAIACVVGTALIILQAPSL 537
            :.::|.:.:|:|||:.|:|:||:.:.||.......|..:....|::
 Worm   495 REREKSKKIEDDWKFSALVVDRICMVIFTSFLFGSTVALFASVPNI 540

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha1NP_001262916.1 LGIC_ECD_nAChR_proto_alpha-like 24..242 CDD:349832 89/217 (41%)
LIC 27..530 CDD:455710 176/535 (33%)
Cys-loop 149..163 CDD:349832 8/13 (62%)
acr-25NP_001023570.2 LGIC_ECD_nAChR 51..231 CDD:349798 78/188 (41%)
Cys-loop 150..164 CDD:349798 8/13 (62%)
LGIC_TM_cation 233..>322 CDD:349853 39/90 (43%)
TM1 helix 233..257 CDD:349853 10/23 (43%)
Neur_chan_memb 239..534 CDD:460753 84/316 (27%)
TM2 helix 265..286 CDD:349853 9/20 (45%)
TM3 helix 297..319 CDD:349853 6/23 (26%)

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