Protein Alignment nAChRalpha1 and nAChRalpha5

DIOPT Version :9

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Alignment Length: 590
• Identity: 219/590 - (37%)
• Similarity: 319/590 - (54%)
• Gaps: 79/590 - (13%)

  Fly     3 SVLFAAVFIALHFATGGLANPDAKRLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLK 67
            |.:|..:::.|. |...||....|||..|||..||.|.|||.|.||.|.:..||.|.|:|||:.|
  Fly   292 SWIFLLIYLNLS-AKVCLAGYHEKRLLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQIIDVDEK 355

  Fly    68 NQIMTTNVWVEQEWNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKAILH 132
            ||::.||||::.||||..|:||..|||||..|.:|...||.||:::||:||..::.|..|..::.
  Fly   356 NQLLVTNVWLKLEWNDMNLRWNTSDYGGVKDLRIPPHRIWKPDVLMYNSADEGFDGTYQTNVVVR 420

  Fly   133 HTGKVVWKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEVGIDL 197
            :.|..::.||.|:||.|:||:.:||||:|.|.||||||||||:.:||    |..|    |.|.|:
  Fly   421 NNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDL----QLQD----ETGGDI 477

  Fly   198 QDYYISVEWDIMRVPAVRNEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSVLVF 262
            ..|.::.||:::.||..|||.:|:||.|||:||.|.:.:||:||:|..|||||||.|:.:::|.|
  Fly   478 SSYVLNGEWELLGVPGKRNEIYYNCCPEPYIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGF 542

  Fly   263 YLPSDSGEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAVLNV 327
            .||.|||||:||.::||||||||..::||.:|.||..|||||.|....|.:|..|||.||.:||.
  Fly   543 TLPPDSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNY 607

  Fly   328 NFRSPVTHRMAPWVQRLFIQILPKLLCIERPKK-----------EEPEEDQPPEVLTDVYHLPP- 380
            :.|:..||.|:.|::.:|:..||.:|.:.||.:           .:...::..::|:|| .|..
  Fly   608 HHRNADTHEMSEWIRIVFLCWLPWILRMSRPGRPLILEFPTTPCSDTSSERKHQILSDV-ELKER 671

  Fly   381 ----------DVDKFVNYDSKRFSGDYGIPALPASHRFDLAAAGGISAHCFAEPPLPSSLPLPGA 435
                      |:|....::.:..:....:|..||.:|                       .:.|.
  Fly   672 SSKSLLANVLDIDDDFRHNCRPMTPGGTLPHNPAFYR-----------------------TVYGQ 713

  Fly   436 DDDLFSPSGLNGDISPGCCPAAAAAAAADLSPTFEKPYAREMEKTIEGSRFIAQHVKNKDKFESV 500
            .||     |..|.|.....|.|........|.|     ..|:...::..|||...::..|:...:
  Fly   714 GDD-----GSIGPIGSTRMPDAVTHHTCIKSST-----EYELGLILKEIRFITDQLRKDDECNDI 768

  Fly   501 EEDWKYVAMVLDRMFLWIFAIACVVGTALIILQAPSLYDQSQP-------------IDILYSKIA 552
            ..|||:.|||:||:.|.||.:..::.|..::|.||.:. .|.|             |::|..|:.
  Fly   769 ANDWKFAAMVVDRLCLIIFTMFTILATIAVLLSAPHII-VSXPYGRGGYCYWFYYKINLLIIKLI 832

  Fly   553 KKKFE 557
            .|.|:
  Fly   833 TKLFK 837

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	Neur_chan_LBD	25..240	CDD:280998	105/214 (49%)
		LIC	27..530	CDD:273305	202/524 (39%)
		Neur_chan_memb	247..530	CDD:280999	94/304 (31%)
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	204/530 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447316
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940