Protein Alignment nAChRalpha1 and nAChRalpha6

DIOPT Version :10

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Alignment Length: 584
• Identity: 201/584 - (34%)
• Similarity: 291/584 - (49%)
• Gaps: 116/584 - (19%)

  Fly     3 SVLFAAVFIALHFATGGLANPDAKRLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLK 67
            |:....:|:|:  .......|..|||.:.|||.||.|.|||.|.|:.|.||.||.|.|:|||:.|
  Fly    10 SLFVLLIFLAI--IKESCQGPHEKRLLNHLLSTYNTLERPVANESEPLEVKFGLTLQQIIDVDEK 72

  Fly    68 NQIMTTNVWVEQEWNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKAILH 132
            |||:|||.|:..|||||.|:||..:||||..|.:....:|.||:::||:||..::.|..|..::.
  Fly    73 NQILTTNAWLNLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHTNIVVK 137

  Fly   133 HTGKVVWKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEVGIDL 197
            |.|..::.||.|:||.|:||:.:||||:|.|.||||||||||..:||        ..|.|.|.||
  Fly   138 HNGSCLYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDL--------VLNSEDGGDL 194

  Fly   198 QDYYISVEWDIMRVPAVRNEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSVLVF 262
            .|:..:.||.::.:|..:|...|:||.|||:||.|.:.:||:||:|..|||:|||.||.:::|.|
  Fly   195 SDFITNGEWYLLAMPGKKNTIVYACCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGF 259

  Fly   263 YLPSDSGEKISLCISILLSLTVFFLLLAEIIPPT-------------SLTV-------------- 300
            .||.|||||::|.::||||||||..|:||.:|.|             ||||
  Fly   260 TLPPDSGEKLTLGVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQVSD 324

  Fly   301 --PLLGKYLLFTMMLVTLSVVVTIAVLNVNFRSPVTHRMAPWVQRLFIQILPKLLCIERP----- 358
              ||||.|....|.:|..|||:|:.|||.:.|:...|.|.||::.:|:|.||.:|.:.||
  Fly   325 AIPLLGTYFNCIMFMVASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWILRMGRPGRKIT 389

  Fly   359 ----------KKEEPEEDQPPEVLTDVYHLPPDVDKFVNYDSKRF--SGDYGIPALPASHRFDLA 411
                      |:.|.:|.....:|.:|..:..|....::......  |..:|.|.....|...:
  Fly   390 RKTILLSNRMKELELKERSSKSLLANVLDIDDDFRHTISGSQTAIGSSASFGRPTTVEEHHTAI- 453

  Fly   412 AAGGISAHCFAEPPLPSSLPLPGADDDLFSPSGLNGDISPGCCPAAAAAAAADLSPTFEKPYARE 476
                                                    ||                   ..::
  Fly   454 ----------------------------------------GC-------------------NHKD 459

  Fly   477 MEKTIEGSRFIAQHVKNKDKFESVEEDWKYVAMVLDRMFLWIFAIACVVGTALIILQAPSLYDQ 540
            :...::..:||...::..|....:..|||:.|||:||..|.:|.:..::.|..::|.||.:..|
  Fly   460 LHLILKELQFITARMRKADDEAELIGDWKFAAMVVDRFCLIVFTLFTIIATVTVLLSAPHIIVQ 523

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	LGIC_ECD_nAChR_proto_alpha-like	24..242	CDD:349832	104/217 (48%)
		LIC	27..530	CDD:455710	192/548 (35%)
		Cys-loop	149..163	CDD:349832	8/13 (62%)
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:455710	197/575 (34%)
		LGIC_ECD_nAChR	55..236	CDD:349798	88/188 (47%)
		Cys-loop	154..168	CDD:349798	8/13 (62%)