DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha1 and nAChRbeta3

DIOPT Version :9

Sequence 1:	NP_001262916.1	Gene:	nAChRalpha1 / 42918	FlyBaseID:	FBgn0000036	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	NP_525098.1	Gene:	nAChRbeta3 / 33228	FlyBaseID:	FBgn0031261	Length:	441	Species:	Drosophila melanogaster

Alignment Length:	538	Identity:	124/538 - (23%)
Similarity:	215/538 - (39%)	Gaps:	133/538 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGSVLFAAVFIALHFATGGLANPDAK---RLYDDLLSNYNRLIRPVGNNS-DRLTVKMGLRLSQL 61
            ||.:|.....:....||....|.:.|   ||:..|.:||:..::||...: ..::::|   :...
  Fly    24 MGMLLMGLTSVPGATATADPKNANVKALDRLHAGLFTNYDSDVQPVFQGTPTNVSLEM---VVTY 85

  Fly    62 IDVNLKNQIMTTNVWVEQEWNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIM 126
            ||::..|..:||:.|:...|.|.:..|.|..|..:..:.:.|..:|.|.|.|:|..:|.  :...
  Fly    86 IDIDELNGKLTTHCWLNLRWRDEERVWQPSQYDNITQITLKSSEVWTPQITLFNGDEGG--LMAE 148

  Fly   127 TKAILHHTGKVVWKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNI 191
            |:..|.|.|...|.|||:|.::||:::..:|.|:|:|.:|.|||   |..|.|.. ..||..::
  Fly   149 TQVTLSHDGHFRWMPPAVYTAYCELNMLNWPHDKQSCKLKIGSW---GLKVVLPE-NGTARGES- 208

  Fly   192 EVGIDLQDYYISVEWDIMRVPAVRNEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISF 256
               :|..|...|.||:|:      :.:.:...::.|..:.:.||.:|::..||..:..|...|..
  Fly   209 ---LDHDDLVQSPEWEIV------DSRAHFVSQDYYGYMEYTLTAQRRSSMYTAVIYTPASCIVI 264

  Fly   257 LSVLVFYLPSD-SGEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVV 320
            |::..|:||.. .||||.:...:::.:..|.:..|:::|..|...||:..:...:::.:::|.:|
  Fly   265 LALSAFWLPPHMGGEKIMINGLLIIVIAAFLMYFAQLLPVLSNNTPLVVIFYSTSLLYLSVSTIV 329

  Fly   321 TIAVLNVNFRSPVTHRMAPWVQRLFIQILPKLLCIERPKKEEPEEDQPPEVLTDVYHLPPDVDKF 385
            .:.||   :.:...|:     :||                        ||.|..:.|
  Fly   330 EVLVL---YLATGKHK-----RRL------------------------PEALRKLLH-------- 354

  Fly   386 VNYDSKRFSGDYGIPALPASHRFDLAAAGGISAHCFAEPPLPSSLPLPGADDDLFSPSGLNGDIS 450
                     |..|...|.:.    .:..|...|....|   ....|...||:...||.|:|....
  Fly   355 ---------GHLGTWLLLSV----FSTTGESQAEKTKE---MDEHPYEEADEQESSPLGINHTEV 403

  Fly   451 PGCCPAAAAAAAADLSPTFEKPYAREMEKTIEGSRFIAQHVKNKDKFESVEEDWKYVAMVLDRM- 514
            ||.                            :.::|                ||..:|..:||:
  Fly   404 PGA----------------------------KANQF----------------DWALLATAVDRIS 424

  Fly   515 -------FLWIFAIACVV 525
                   || |.||.|.|
  Fly   425 FVSFSLAFL-ILAIRCSV 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	Neur_chan_LBD	25..240	CDD:280998	61/218 (28%)
		LIC	27..530	CDD:273305	117/509 (23%)
		Neur_chan_memb	247..530	CDD:280999	55/288 (19%)
nAChRbeta3	NP_525098.1	LIC	39..437	CDD:273305	117/517 (23%)
		Neur_chan_LBD	52..247	CDD:280998	59/213 (28%)
		Neur_chan_memb	255..434	CDD:280999	50/279 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447345
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840