Protein Alignment nAChRalpha1 and nAChRalpha7

DIOPT Version :10

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_001162795.1
• Gene: nAChRalpha7 / 32928
• FlyBaseID: FBgn0086778
• Length: 564
• Species: Drosophila melanogaster
• Alignment Length: 541
• Identity: 208/541 - (38%)
• Similarity: 302/541 - (55%)
• Gaps: 68/541 - (12%)

  Fly    21 ANPDAKRLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLKNQIMTTNVWVEQEWNDYK 85
            |.|..|||...||.|||.|.|||.|.||.|.:..||.|.|:|||:.|||::.||:|::.||||..
  Fly    57 AGPHEKRLLHALLDNYNSLERPVVNESDPLQLSFGLTLMQIIDVDEKNQLLITNIWLKLEWNDMN 121

  Fly    86 LKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKAILHHTGKVVWKPPAIYKSFCE 150
            |:||..::|||..|.:|...:|.||:::||:||..::.|..|..::.:.|..::.||.|:||.|:
  Fly   122 LRWNSSEFGGVRDLRIPPHRLWKPDVLMYNSADEGFDGTYATNVVVRNNGSCLYVPPGIFKSTCK 186

  Fly   151 IDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEVGIDLQDYYISVEWDIMRVPAVR 215
            ||:.:||||:|.|.||||||||||:.:||    |..|    |.|.|:..:..:.|||::.||..|
  Fly   187 IDITWFPFDDQRCEMKFGSWTYDGFQLDL----QLQD----EAGGDISSFITNGEWDLLGVPGKR 243

  Fly   216 NEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSVLVFYLPSDSGEKISLCISILL 280
            ||.:|:||.|||:||.|.:.:|||||:|..|||:|||.|:.:::|.|.||.|||||:||.::|||
  Fly   244 NEIYYNCCPEPYIDITFAILIRRKTLYYFFNLIVPCVLIASMALLGFTLPPDSGEKLSLGVTILL 308

  Fly   281 SLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAVLNVNFRSPVTHRMAPWVQRLF 345
            |||||..::||.:|.||..|||||.|....|.:|..|||.||.:||.:.|:|.||.|:.|::.:|
  Fly   309 SLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNPDTHEMSEWIRVIF 373

  Fly   346 IQILPKLLCIERP---------------------KKE-----EPEEDQPPEVLTDVYHLPPDVDK 384
            :..||.:|.::||                     ||:     |.:|.....:|.:|.    |:|
  Fly   374 LYWLPCILRMQRPGQVGYECPPPPSSSSSSASGEKKQQIQNVELKERSSKSLLANVL----DID- 433

  Fly   385 FVNYDSKRFSGDYGIPALPASHRFDLAAAGGISAHCFAEPPLPSSLPLPGADDDLFSPSGLNGDI 449
                |..|           .:||    .|.....|   :|....::...| ||....|.|..|.:
  Fly   434 ----DDFR-----------CNHR----CASATLPH---QPTYYRTMYRQG-DDGSVGPVGPAGPV 475

  Fly   450 SPGCCPAAAAAAAADLSPTFEKPYAREMEKTIEGSRFIAQHVKNKDKFESVEEDWKYVAMVLDRM 514
            ..|....|.:......|..:      |:...::..|:|.:.:|.:|:...:..|||:.|||:||:
  Fly   476 VDGRLHEAISHTCLTSSAEY------ELALILKELRWITEQLKKEDETSDITRDWKFAAMVVDRL 534

  Fly   515 FLWIFAIACVVGTALIILQAP 535
            .|.||.:..::.|..::..||
  Fly   535 CLIIFTLFTIIATLAVLFSAP 555

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	LGIC_ECD_nAChR_proto_alpha-like	24..242	CDD:349832	103/217 (47%)
		LIC	27..530	CDD:455710	203/528 (38%)
		Cys-loop	149..163	CDD:349832	8/13 (62%)
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:455710	204/530 (38%)