Protein Alignment nAChRalpha1 and CG8916

DIOPT Version :10

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_573090.3
• Gene: CG8916 / 32553
• FlyBaseID: FBgn0030707
• Length: 612
• Species: Drosophila melanogaster
• Alignment Length: 399
• Identity: 84/399 - (21%)
• Similarity: 162/399 - (40%)
• Gaps: 64/399 - (16%)

  Fly    16 ATGGLANPDAKRLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLKNQIMTTNVWVEQE 80
            |...:.:.:...:.::||..|.:...|.........|:..:.:..:..|:..:...:.:.:..|.
  Fly    99 AAADMLSRNISMILENLLKRYEQSQLPTHGQGVPTVVQTNILIRSMGPVSELDMDYSMDCYFRQY 163

  Fly    81 WNDYKLKWNPDDYGGVDTLHVP---SEHIWLPDIVLYNNADGN-YEVTIMTKAI-LHHTGKVVWK 140
            |.|.:|.:.    |.:.:|.:.   .:.||.||...||..... :.:|:..|.: |...|.:::.
  Fly   164 WRDKRLSFK----GPIKSLSLSIKMLDKIWRPDTYFYNGKHSQIHMITVPNKLLRLDQNGGILYS 224

  Fly   141 PPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEVGIDLQDYYISVE 205
            .....|:.|.::::.||.|.|:|.:..||:.|....: :...|...|:.:...|:.|.      :
  Fly   225 MRLTIKATCPMELQNFPMDRQSCPLVIGSYGYINQQL-IYEWKNQDDAVSFVPGMTLN------Q 282

  Fly   206 WDIMRV-----PAVRNEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSVLVFYLP 265
            :|::.:     ..||.|..:|     .|.:.||  |:|.|.::.:.:.:||:.|..||.:.|::.
  Fly   283 FDLISMMHRNFTTVRREGDFS-----VLHVAFN--LKRHTGYFLIQVYVPCILIVVLSWVSFWIH 340

  Fly   266 SD-SGEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAVLNVNF 329
            .: :.:::|||::.:|:|:...|.....:|..        ||.......:.:|.:..||.| :.|
  Fly   341 REATSDRVSLCVTSVLTLSTISLDSRTDLPKV--------KYATALDWFLLMSFLYCIATL-LEF 396

  Fly   330 RSPVTHRMAPWVQRLFIQILPKLLCIERPKKEEPEE---------DQPPEVLTDVYHLPPDVDKF 385
            ..              :....||...|.|:.|:..|         |...||..|.   ..|.|.|
  Fly   397 AG--------------VHYFTKLGSGESPQLEDQWEDICIANSLSDHAGEVDGDG---EADADPF 444

  Fly   386 VNYDSKRFS 394
            .:.||...|
  Fly   445 ADEDSSNGS 453

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	LGIC_ECD_nAChR_proto_alpha-like	24..242	CDD:349832	47/227 (21%)
		LIC	27..530	CDD:455710	83/388 (21%)
		Cys-loop	149..163	CDD:349832	5/13 (38%)
CG8916	NP_573090.3	LIC	92..598	CDD:455710	84/399 (21%)
		LGIC_ECD_GABAR_GRD-like	132..314	CDD:349808	41/199 (21%)
		Cys-loop	233..247	CDD:349808	5/13 (38%)