DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRalpha1 and nAChRalpha3

DIOPT Version :9

Sequence 1:NP_001262916.1 Gene:nAChRalpha1 / 42918 FlyBaseID:FBgn0000036 Length:597 Species:Drosophila melanogaster
Sequence 2:NP_001285015.1 Gene:nAChRalpha3 / 31767 FlyBaseID:FBgn0015519 Length:795 Species:Drosophila melanogaster


Alignment Length:773 Identity:337/773 - (43%)
Similarity:418/773 - (54%) Gaps:229/773 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 VFIALHFATGGLANPDAKRLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLKNQIMTT 73
            :.:.|.|.:...|||||||||||||||||:|:|||.|.:|.|||::.|:||||||||||||||||
  Fly    10 MILVLSFISSSTANPDAKRLYDDLLSNYNKLVRPVVNVTDALTVRIKLKLSQLIDVNLKNQIMTT 74

  Fly    74 NVWVEQEWNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKAILHHTGKVV 138
            |:||||.|.||||||.|.:||||:.|||||:|||.||||||||||||:|||:.|||.|::||:|.
  Fly    75 NLWVEQSWYDYKLKWEPKEYGGVEMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATLNYTGRVE 139

  Fly   139 WKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEVGIDLQDYYIS 203
            |:|||||||.|||||||||||||||.||||||||||:.|||||:.:...::.:|||:||.::|.|
  Fly   140 WRPPAIYKSSCEIDVEYFPFDEQTCVMKFGSWTYDGFQVDLRHIDELNGTNVVEVGVDLSEFYTS 204

  Fly   204 VEWDIMRVPAVRNEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSVLVFYLPSDS 268
            |||||:.||||||||||:||:||||||.||:|:|||||||||||||||:|||||::|||||||||
  Fly   205 VEWDILEVPAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNLIIPCMGISFLTILVFYLPSDS 269

  Fly   269 GEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAVLNVNFRSPV 333
            |||:||.|||||||||||||||||||||||.||||||::||||:|.|.|:.||:.|||::||||.
  Fly   270 GEKVSLSISILLSLTVFFLLLAEIIPPTSLVVPLLGKFVLFTMILDTFSICVTVLVLNIHFRSPQ 334

  Fly   334 THRMAPWVQRLFIQILPKLLCIERPKKEEPE------------------EDQ-----PPEVLTDV 375
            ||.|||||:.:||..||:.|.:.||.....|                  .||     ||..|:.:
  Fly   335 THTMAPWVRTVFINQLPRFLVMRRPLYPISEMIKSSRRLMVRTCNGLELRDQIPPLPPPVALSRM 399

  Fly   376 YHLPPDVDKFVNYDSKRFSGDYGI----------------------------------------- 399
            :|.|....:..:...:.....|.:                                         
  Fly   400 HHSPKTTSRSTSPHLQHRVQTYNLMDECGMGMGGGASTITGHLSSLYPPTMSTANQQTSTTSSLI 464

  Fly   400 ------------------PALPASHRFDLAAA--------------GGISAH------------- 419
                              |..|...|...:.:              ||...|             
  Fly   465 DAQYHNQYQQTGGSLLDHPLTPTKFRQMTSTSSQTGQNGSGNGNGNGGYGGHGQSGGHHLYRQQS 529

  Fly   420 -CFAE-PPLP-----SSLPLPGADDDLFSPSGLN-----------GDISPGCC------------ 454
             |.|. .|||     :......:|..:.:|:.:.           ..::..||            
  Fly   530 SCSANFSPLPQHAHQAHASTTTSDLGMANPNVIKSTTTVNSVATASTLADSCCSGTIQIHQGMGA 594

  Fly   455 ------------------------------------------------------------PAAAA 459
                                                                        .||||
  Fly   595 GAACQSSELLHHQQLHHQQMHHQQQQQQQQQHHHHQRPTTSAAAAAAAAAAGGPSTSAAAAAAAA 659

  Fly   460 AAAA-------------DLSPTFEK---PY--------------AREMEKTIEGSRFIAQHVKNK 494
            ||||             |:.|..::   |:              ..|:.|.::|..:||...:.:
  Fly   660 AAAAGTPPPPPPPAGVCDILPACQREGGPHCCSGRGNVRQRWHTCPELHKAMDGVTYIADQTRKE 724

  Fly   495 DKFESVEEDWKYVAMVLDRMFLWIFAIACVVGTALIILQAPSLYDQSQPIDILYSKIA 552
            ::...|:||||||||||||:|||||.||.|||||.||||||:|||...||||..|:||
  Fly   725 EESTRVKEDWKYVAMVLDRLFLWIFTIAVVVGTAGIILQAPTLYDTRMPIDIKLSEIA 782

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha1NP_001262916.1 Neur_chan_LBD 25..240 CDD:280998 159/214 (74%)
LIC 27..530 CDD:273305 313/731 (43%)
Neur_chan_memb 247..530 CDD:280999 148/511 (29%)
nAChRalpha3NP_001285015.1 Neur_chan_LBD 26..241 CDD:280998 159/214 (74%)
Neur_chan_memb 248..>359 CDD:280999 81/110 (74%)
Neur_chan_memb <683..760 CDD:280999 31/76 (41%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45447336
Domainoid 1 1.000 250 1.000 Domainoid score I2065
eggNOG 1 0.900 - - E1_KOG3645
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 473 1.000 Inparanoid score I1461
Isobase 1 0.950 - 0 Normalized mean entropy S4201
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D188416at33208
OrthoFinder 1 1.000 - - FOG0000583
OrthoInspector 1 1.000 - - mtm6399
orthoMCL 1 0.900 - - OOG6_101158
Panther 1 1.100 - - P PTHR18945
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X294
1211.750

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