Protein Alignment nAChRalpha1 and chrnb3b

DIOPT Version :9

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_775394.1
• Gene: chrnb3b / 317643
• ZFINID: ZDB-GENE-030102-4
• Length: 462
• Species: Danio rerio
• Alignment Length: 547
• Identity: 225/547 - (41%)
• Similarity: 304/547 - (55%)
• Gaps: 107/547 - (19%)

  Fly     5 LFAAVFI---ALHFATGGLA-NPDAKRLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVN 65
            ||.::|.   |..|.:  || ..||  |..||...|.|.:||:.:.:..:.|:.||::|||:||:
Zfish    11 LFTSIFATTPAREFVS--LAEREDA--LLRDLFQGYQRWVRPILHANHTVKVRFGLKISQLVDVD 71

  Fly    66 LKNQIMTTNVWVEQEWNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKAI 130
            .|||:||||||:.:||.||||:|||::|||:..:.||||.|||||||||.||||.:|.:||||||
Zfish    72 EKNQLMTTNVWLYEEWLDYKLRWNPENYGGITFIRVPSESIWLPDIVLYENADGRFEGSIMTKAI 136

  Fly   131 LHHTGKVVWKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEVGI 195
            :.:.|.:.|.|||.|||.|.:||.:||||.|.|.||||||||||.||:|..:...         :
Zfish   137 VRYNGLITWTPPASYKSACTMDVTFFPFDRQNCSMKFGSWTYDGNMVELVLVNHQ---------V 192

  Fly   196 DLQDYYISVEWDIMRV---PAVRNEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISFL 257
            |..|::.:.||:|:..   ...|.:..||   .||  |.::..|:|..||||:.|||||:|:|||
Zfish   193 DRSDFFDNGEWEILSATGHKGSRRDGHYS---YPY--ITYSFILKRLPLFYTLFLIIPCLGLSFL 252

  Fly   258 SVLVFYLPSDSGEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTI 322
            :|||||||||.|||:||..|:|:|||||.|::.||||.:|..:||:|:||||.|:.||||::||:
Zfish   253 TVLVFYLPSDEGEKVSLSTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLLFIMIFVTLSIIVTV 317

  Fly   323 AVLNVNFRSPVT-HRMAPWVQRLFIQILPKLLCIERPKKEEPEEDQPPEVLTDVYHLPPDVDKFV 386
            .|:||:.||..| |.|:|||:.||:|.||.|||:...              ||.||.|.
Zfish   318 FVINVHHRSSATYHPMSPWVRTLFLQRLPDLLCMRGN--------------TDRYHYPQ------ 362

  Fly   387 NYDSKRFSGDYGIPALPASHRFDLAAAGGISAHCFAEPPLPSSLPLPGADDDLFSPSGLNGDISP 451
                                               .||..|...|....     .|.|..||
Zfish   363 -----------------------------------MEPQSPDLKPRSKK-----GPPGPEGD--- 384

  Fly   452 GCCPAAAAAAAADLSPTFEKPYAREMEKTIEGSRFIAQHVKNKDKFESVEEDWKYVAMVLDRMFL 516
                   ..|..::           :|:.....|:|::|:|.:.....|.:|||:||.||||:||
Zfish   385 -------GQALINM-----------LEQATNSVRYISRHIKKEHFIREVVQDWKFVAQVLDRIFL 431

  Fly   517 WIFAIACVVGTALIILQAPSLYDQSQP 543
            |.|....|:||.||...|..::..:.|
Zfish   432 WAFLTVSVLGTILIFTPAVKMFLSTPP 458

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	Neur_chan_LBD	25..240	CDD:280998	104/217 (48%)
		LIC	27..530	CDD:273305	212/506 (42%)
		Neur_chan_memb	247..530	CDD:280999	105/283 (37%)
chrnb3b	NP_775394.1	LIC	5..449	CDD:273305	223/536 (42%)
		Neur_chan_LBD	31..235	CDD:280998	105/219 (48%)
		Neur_chan_memb	242..446	CDD:280999	106/284 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45250
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.830