Protein Alignment nAChRalpha1 and chrnb3b

DIOPT Version :10

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_775394.1
• Gene: chrnb3b / 317643
• ZFINID: ZDB-GENE-030102-4
• Length: 462
• Species: Danio rerio
• Alignment Length: 547
• Identity: 225/547 - (41%)
• Similarity: 304/547 - (55%)
• Gaps: 107/547 - (19%)

  Fly     5 LFAAVFI---ALHFATGGLA-NPDAKRLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVN 65
            ||.::|.   |..|.:  || ..||  |..||...|.|.:||:.:.:..:.|:.||::|||:||:
Zfish    11 LFTSIFATTPAREFVS--LAEREDA--LLRDLFQGYQRWVRPILHANHTVKVRFGLKISQLVDVD 71

  Fly    66 LKNQIMTTNVWVEQEWNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKAI 130
            .|||:||||||:.:||.||||:|||::|||:..:.||||.|||||||||.||||.:|.:||||||
Zfish    72 EKNQLMTTNVWLYEEWLDYKLRWNPENYGGITFIRVPSESIWLPDIVLYENADGRFEGSIMTKAI 136

  Fly   131 LHHTGKVVWKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEVGI 195
            :.:.|.:.|.|||.|||.|.:||.:||||.|.|.||||||||||.||:|..:...         :
Zfish   137 VRYNGLITWTPPASYKSACTMDVTFFPFDRQNCSMKFGSWTYDGNMVELVLVNHQ---------V 192

  Fly   196 DLQDYYISVEWDIMRV---PAVRNEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISFL 257
            |..|::.:.||:|:..   ...|.:..||   .||  |.::..|:|..||||:.|||||:|:|||
Zfish   193 DRSDFFDNGEWEILSATGHKGSRRDGHYS---YPY--ITYSFILKRLPLFYTLFLIIPCLGLSFL 252

  Fly   258 SVLVFYLPSDSGEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTI 322
            :|||||||||.|||:||..|:|:|||||.|::.||||.:|..:||:|:||||.|:.||||::||:
Zfish   253 TVLVFYLPSDEGEKVSLSTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLLFIMIFVTLSIIVTV 317

  Fly   323 AVLNVNFRSPVT-HRMAPWVQRLFIQILPKLLCIERPKKEEPEEDQPPEVLTDVYHLPPDVDKFV 386
            .|:||:.||..| |.|:|||:.||:|.||.|||:...              ||.||.|.
Zfish   318 FVINVHHRSSATYHPMSPWVRTLFLQRLPDLLCMRGN--------------TDRYHYPQ------ 362

  Fly   387 NYDSKRFSGDYGIPALPASHRFDLAAAGGISAHCFAEPPLPSSLPLPGADDDLFSPSGLNGDISP 451
                                               .||..|...|....     .|.|..||
Zfish   363 -----------------------------------MEPQSPDLKPRSKK-----GPPGPEGD--- 384

  Fly   452 GCCPAAAAAAAADLSPTFEKPYAREMEKTIEGSRFIAQHVKNKDKFESVEEDWKYVAMVLDRMFL 516
                   ..|..::           :|:.....|:|::|:|.:.....|.:|||:||.||||:||
Zfish   385 -------GQALINM-----------LEQATNSVRYISRHIKKEHFIREVVQDWKFVAQVLDRIFL 431

  Fly   517 WIFAIACVVGTALIILQAPSLYDQSQP 543
            |.|....|:||.||...|..::..:.|
Zfish   432 WAFLTVSVLGTILIFTPAVKMFLSTPP 458

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	LGIC_ECD_nAChR_proto_alpha-like	24..242	CDD:349832	105/220 (48%)
		LIC	27..530	CDD:455710	212/506 (42%)
		Cys-loop	149..163	CDD:349832	8/13 (62%)
chrnb3b	NP_775394.1	LIC	5..449	CDD:455710	223/536 (42%)