Protein Alignment nAChRalpha1 and Chrne

DIOPT Version :10

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: XP_017452660.1
• Gene: Chrne / 29422
• RGDID: 2353
• Length: 547
• Species: Rattus norvegicus
• Alignment Length: 525
• Identity: 173/525 - (32%)
• Similarity: 264/525 - (50%)
• Gaps: 80/525 - (15%)

  Fly    28 LYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLKNQIMTTNVWVEQEWNDYKLKWNPDD 92
            ||..|..||:...|||....|.:|:.:.:.|:.||.:|.|.:.:||:||:..||.||:|.::.||
  Rat    80 LYHHLFDNYDPECRPVRRPEDTVTITLKVTLTNLISLNEKEETLTTSVWIGIEWQDYRLNFSKDD 144

  Fly    93 YGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKAILHHTGKVVWKPPAIYKSFCEIDVEYFP 157
            :.||:.|.|||||:|||:|||.||.||.:.|......:::..|.|.|.|||||:|.|.::|.|||
  Rat   145 FAGVEILRVPSEHVWLPEIVLENNIDGQFGVAYDCNVLVYEGGSVSWLPPAIYRSTCAVEVTYFP 209

  Fly   158 FDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNI--EVGIDLQDYYISVEWDIMRVPAVRNEKFY 220
            ||.|.|.:.|.|.||:...|:.  :....|..|.  ::.||...:..:.||.|...|.:......
  Rat   210 FDWQNCSLIFRSQTYNAEEVEF--IFAVDDDGNAINKIDIDTAAFTENGEWAIDYCPGMIRHYEG 272

  Fly   221 SCCEEP-YLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSVLVFYLPSDS-GEKISLCISILLSLT 283
            ...|:| ..|:::.|.:|||.|||.:|:|:|||.||.|.:|.::||:.: |:|.::.|::||:.|
  Rat   273 GSTEDPGETDVIYTLIIRRKPLFYVINIIVPCVLISGLVLLAYFLPAQAGGQKCTVSINVLLAQT 337

  Fly   284 VFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAVLNVNFRSPVTHRMAPWVQRLFIQI 348
            ||..|:|:.||.|||:|||||:||:|.|::.||.|:..:.||||:.|:|.||..:|.::::.:::
  Rat   338 VFLFLIAQKIPETSLSVPLLGRYLIFVMVVATLIVMNCVIVLNVSLRTPTTHATSPRLRQILLEL 402

  Fly   349 LPKLLCIERPKKEEPEEDQPPEVLTDVYHLPPDVDKFVNYDSKRFSGDYGIPALPASH------R 407
            ||:||.:. |..|:|....|                      .|.:...|| .|.|..      |
  Rat   403 LPRLLGLS-PPPEDPGAASP----------------------ARRASSVGI-LLRAEELILKKPR 443

  Fly   408 FDLAAAGGISAHCFAEPPLPSSLPLPGADDDLFSPSGLNGDISPGCCPAAAAAAAADLSPTFEKP 472
            .:|...|....|              |.                    ..|||...:||..
  Rat   444 SELVFEGQRHRH--------------GT--------------------WTAAALCQNLSAA---- 470

  Fly   473 YAREMEKTIEGSRFIAQHVKNKDKFESVEEDWKYVAMVLDRMFLWIFAIACVVGTALIIL----- 532
             |.|:...::...|:|:..::::.......||..:...||.:..|...:...||:.||.|
  Rat   471 -APEVRCCVDAVNFVAESTRDQEATGEELSDWVRMGKALDNVCFWAALVLFSVGSTLIFLGGYFN 534

  Fly   533 QAPSL 537
            |.|.|
  Rat   535 QVPDL 539

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	LGIC_ECD_nAChR_proto_alpha-like	24..242	CDD:349832	83/216 (38%)
		LIC	27..530	CDD:455710	167/511 (33%)
		Cys-loop	149..163	CDD:349832	8/13 (62%)
Chrne	XP_017452660.1	LGIC_ECD_nAChR_E	102..292	CDD:349831	72/191 (38%)
		Cys-loop	201..215	CDD:349831	8/13 (62%)
		Neur_chan_memb	300..528	CDD:460753	81/290 (28%)