DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha1 and Chrng

DIOPT Version :9

Sequence 1:	NP_001262916.1	Gene:	nAChRalpha1 / 42918	FlyBaseID:	FBgn0000036	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	NP_062018.1	Gene:	Chrng / 25753	RGDID:	2354	Length:	519	Species:	Rattus norvegicus

Alignment Length:	552	Identity:	180/552 - (32%)
Similarity:	274/552 - (49%)	Gaps:	80/552 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 VFIALHFATGGLANPDAKRLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLKNQIMTT 73
            :.:.|....|..:....:||..||:.||:..:||...:||.:.|.:.|.|:.||.:|.:.:.:||
  Rat    10 LLLLLATCLGAQSRNQEERLLADLMRNYDPHLRPAERDSDVVNVSLKLTLTNLISLNEREEALTT 74

  Fly    74 NVWVEQEWNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKAILHHTGKVV 138
            |||:|.:|.||:|:|:|.||.|:..|.|||..:|.|||||.||.||.:||.:....::...|.:.
  Rat    75 NVWIEMQWCDYRLRWDPKDYEGLWILRVPSTMVWQPDIVLGNNVDGVFEVALYCNVLVSPDGCIY 139

  Fly   139 WKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIE-VGIDLQDYYI 202
            |.||||::|.|.|.|.|||||.|.|.:.|.|.||....::|: |.| .|...|| :.||.:.:..
  Rat   140 WLPPAIFRSSCSISVTYFPFDWQNCSLVFQSQTYSTSEINLQ-LSQ-EDGQAIEWIFIDPEAFTE 202

  Fly   203 SVEWDIMRVPAVRNEKFYSCCEEP-YLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSVLVFYLPS 266
            :.||.|...||.......:..||. :..:||.|.::||.|||.:|:|:|||.||.:::|:::||:
  Rat   203 NGEWAIRHRPAKMLLDPVTPAEEAGHQKVVFYLLIQRKPLFYVINIIVPCVLISSVAILIYFLPA 267

  Fly   267 DS-GEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAVLNVNFR 330
            .: |:|.::..::||:.|||..|:|:.:|.||..|||:.|||.|.|::..|.||.::.||||:.|
  Rat   268 KAGGQKCTVATNVLLAQTVFLFLVAKKVPETSQAVPLISKYLTFLMVVTILIVVNSVVVLNVSLR 332

  Fly   331 SPVTHRMAPWVQRLFIQILPKLLCIERPKKEEPEEDQPPEVLTDVYHLPPDVDKFVNYDSKRF-- 393
            ||.||.||..|:::|:::||:||.:                     |:.|.....|.....|.
  Rat   333 SPHTHSMARGVRKVFLRLLPQLLRM---------------------HVHPRAPAAVQDARLRLQN 376

  Fly   394 SGDYGIPALPASHRFDLAAAGGISAHCFAEPPLPSSLPLPGADDDLFSPSGLNGDI--------- 449
            ....|.|.: .....||.              ||.|       :.||.....||.:
  Rat   377 GSSSGWPIM-TREEGDLC--------------LPRS-------ELLFRQRQRNGLVQAVLEKLEN 419

  Fly   450 ------SPGCCPAAAAAAAADLSPTFEKPYAREMEKTIEGSRFIAQHVKNKDKFESVEEDWKYVA 508
                  |...|.:...|:.|             ::..::....:|:....:..|:|..|:|..|.
  Rat   420 GPEMRQSQEFCGSLKQASPA-------------IQACVDACNLMARARHQQSHFDSGNEEWLLVG 471

  Fly   509 MVLDRMFLWIFAIACVVGTALIILQAPSLYDQ 540
            .||||:.........:.|||.|.|.|.  |:|
  Rat   472 RVLDRVCFLAMLSLFICGTAGIFLMAH--YNQ 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	Neur_chan_LBD	25..240	CDD:280998	87/216 (40%)
		LIC	27..530	CDD:273305	173/522 (33%)
		Neur_chan_memb	247..530	CDD:280999	81/300 (27%)
Chrng	NP_062018.1	LIC	23..497	CDD:273305	175/531 (33%)
		Neur_chan_LBD	26..241	CDD:280998	87/216 (40%)
		Neur_chan_memb	248..494	CDD:280999	81/301 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910