Protein Alignment nAChRalpha1 and GABRG2

DIOPT Version :10

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_944493.2
• Gene: GABRG2 / 2566
• HGNCID: 4087
• Length: 515
• Species: Homo sapiens
• Alignment Length: 359
• Identity: 74/359 - (20%)
• Similarity: 145/359 - (40%)
• Gaps: 68/359 - (18%)

  Fly    24 DAKRLYDDLLSNYNRLIRP-VGNNSDRLTVKMGLRLSQLIDVNLKNQIMTTNVWVEQEWNDYKLK 87
            |...:.::||..|:..:|| :|.....:...|  .::.:..||..|...|.:::..|.|.|.:||
Human    65 DVTVILNNLLEGYDNKLRPDIGVKPTLIHTDM--YVNSIGPVNAINMEYTIDIFFAQTWYDRRLK 127

  Fly    88 WNPDDYGGVDTLHVPSE---HIWLPDIVLYNN--ADGNYEVTIMTKAILHHTGKVVWKPPAIYKS 147
            :|    ..:..|.:.|.   .||:||....|:  ||.::..|......:.:.|:|::.......:
Human   128 FN----STIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDA 188

  Fly   148 FCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQ------------------TADSDNIEVG 194
            .|::.:..||.||.:|.::|.||:        |.:.|                  :.|...:...
Human   189 ECQLQLHNFPMDEHSCPLEFSSWS--------RSIAQAGMCSGVISAHYSLRFWGSTDPPTLASR 245

  Fly   195 I-DLQDYY----ISVEW--DIMRVPAVRNEKFY----------------SCCEEPYLDIVFNLTL 236
            : .:.|.|    |..:|  ..:.|...|:.:.|                :..:...:.:.|:|:
Human   246 VAGISDGYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTTEVVKTTSGDYVVMSVYFDLS- 309

  Fly   237 RRKTLFYTVNLIIPCVGISFLSVLVFYLPSDS-GEKISLCISILLSLTVFFLLLAEIIPPTSLTV 300
             |:..::|:...|||..|..||.:.|::..|: ..:.||.|:.:|::|....:..:.:|..|...
Human   310 -RRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYVT 373

  Fly   301 PLLGKYLLFTMMLVTLSVVVTIAVLN--VNFRSP 332
            .:  ...:....:...|.:|....|:  |:.|.|
Human   374 AM--DLFVSVCFIFVFSALVEYGTLHYFVSNRKP 405

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	LGIC_ECD_nAChR_proto_alpha-like	24..242	CDD:349832	52/264 (20%)
		LIC	27..530	CDD:455710	73/356 (21%)
		Cys-loop	149..163	CDD:349832	5/13 (38%)
GABRG2	NP_944493.2	LIC	69..512	CDD:455710	73/355 (21%)
		LGIC_ECD_GABAAR_G	90..311	CDD:349801	44/236 (19%)
		Cys-loop	190..204	CDD:349801	5/13 (38%)