DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRalpha1 and Chrna5

DIOPT Version :9

Sequence 1:NP_001262916.1 Gene:nAChRalpha1 / 42918 FlyBaseID:FBgn0000036 Length:597 Species:Drosophila melanogaster
Sequence 2:NP_058774.2 Gene:Chrna5 / 25102 RGDID:2347 Length:467 Species:Rattus norvegicus


Alignment Length:527 Identity:209/527 - (39%)
Similarity:291/527 - (55%) Gaps:116/527 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    18 GGL-----ANPDAKRLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLKNQIMTTNVWV 77
            |||     |......|:.||..:|.|.:|||.:.||::.:|.||.:|||:||:.|||:||||||:
  Rat    35 GGLPELSSAAKHEDSLFRDLFEDYERWVRPVEHLSDKIKIKFGLAISQLVDVDEKNQLMTTNVWL 99

  Fly    78 EQEWNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKAILHHTGKVVWKPP 142
            :|||.|.||:||||||||:..:.|||:.:|:|||||::||||.:| ...||.::.:.|.|.|..|
  Rat   100 KQEWIDVKLRWNPDDYGGIKIIRVPSDSLWIPDIVLFDNADGRFE-GASTKTVVRYNGTVTWTQP 163

  Fly   143 AIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEVGIDLQDYYISVEWD 207
            |.|||.|.|||.:||||.|.|.||||||||||..||:    ...|.|     :|..|::.:.||:
  Rat   164 ANYKSSCTIDVTFFPFDLQNCSMKFGSWTYDGSQVDI----ILEDQD-----VDRTDFFDNGEWE 219

  Fly   208 IMRVPAVRNEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSVLVFYLPSDSGEKI 272
            ||.....:..:..|||..||  |.::..::|..||||:.|||||:|:|||:|:||||||:.||||
  Rat   220 IMSAMGSKGNRTDSCCWYPY--ITYSFVIKRLPLFYTLFLIIPCIGLSFLTVVVFYLPSNEGEKI 282

  Fly   273 SLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAVLNVNFRSPVTHR- 336
            |||.|:|:|||||.|::.||||.:|..:||:|:||:|||:.||||::||:..:|::.||..||. 
  Rat   283 SLCTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLVFTMIFVTLSIMVTVFAINIHHRSSSTHNA 347

  Fly   337 MAPWVQRLFIQILPKLLCIERPKKEEPEEDQPPEVLTDVYHLPPDVDKFVNYDSKRFSGDYGIPA 401
            |||||:::|:..||||||:.                       ...|::.....:..||      
  Rat   348 MAPWVRKIFLHKLPKLLCMR-----------------------SHADRYFTQREEAESG------ 383

  Fly   402 LPASHRFDLAAAGGISAHCFAEPPLPSSLPLPGADDDLFSPSGLNGDISPGCCPAAAAAAAADLS 466
                       ||                           |...|                    
  Rat   384 -----------AG---------------------------PKSRN-------------------- 390

  Fly   467 PTFEKPYAREMEKTIEGSRFIAQHVKNKDKFESVEEDWKYVAMVLDRMFLWIFAIACVVGTALII 531
                     .:|..::..|:|.:||..::....|.||||::|.||||||||.|.:..::||  :.
  Rat   391 ---------TLEAALDCIRYITRHVVKENDVREVVEDWKFIAQVLDRMFLWTFLLVSIIGT--LG 444

  Fly   532 LQAPSLY 538
            |..|.:|
  Rat   445 LFVPVIY 451

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha1NP_001262916.1 Neur_chan_LBD 25..240 CDD:280998 102/214 (48%)
LIC 27..530 CDD:273305 202/503 (40%)
Neur_chan_memb 247..530 CDD:280999 96/283 (34%)
Chrna5NP_058774.2 LIC 41..448 CDD:273305 204/516 (40%)
Neur_chan_LBD 47..250 CDD:280998 102/214 (48%)
Neur_chan_memb 257..446 CDD:280999 96/286 (34%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 253 1.000 Domainoid score I1995
eggNOG 1 0.900 - - E1_KOG3645
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG45250
OrthoDB 1 1.010 - - D188416at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
65.830

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