DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRalpha1 and Chrna3

DIOPT Version :9

Sequence 1:NP_001262916.1 Gene:nAChRalpha1 / 42918 FlyBaseID:FBgn0000036 Length:597 Species:Drosophila melanogaster
Sequence 2:NP_434692.2 Gene:Chrna3 / 25101 RGDID:2345 Length:499 Species:Rattus norvegicus


Alignment Length:539 Identity:237/539 - (43%)
Similarity:339/539 - (62%) Gaps:54/539 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MGSVL----FAAVFIALHFATGGLANPDAKRLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQL 61
            ||.||    .:.:.:.|.......|:....||:..|..:||.:||||.|.|..:.::..:.:|||
  Rat     1 MGVVLLPPPLSMLMLVLMLLPAASASEAEHRLFQYLFEDYNEIIRPVANVSHPVIIQFEVSMSQL 65

  Fly    62 IDVNLKNQIMTTNVWVEQEWNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIM 126
            :.|:..||||.||:|::|.||||||||.|.||.||:.:.||:|.||.|||||||||||:::|...
  Rat    66 VKVDEVNQIMETNLWLKQIWNDYKLKWKPSDYQGVEFMRVPAEKIWKPDIVLYNNADGDFQVDDK 130

  Fly   127 TKAILHHTGKVVWKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNI 191
            |||:|.:||:|.|.||||:||.|:|||.|||||.|.|.||||||:||...:||           :
  Rat   131 TKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDL-----------V 184

  Fly   192 EVG--IDLQDYYISVEWDIMRVPAVRNEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGI 254
            .:|  ::|:||:.|.||.|::.|..::|..|:||||.|.||.::|.:||..||||:||||||:.|
  Rat   185 LIGSSMNLKDYWESGEWAIIKAPGYKHEIKYNCCEEIYQDITYSLYIRRLPLFYTINLIIPCLLI 249

  Fly   255 SFLSVLVFYLPSDSGEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVV 319
            |||:|||||||||.|||::||||:|||||||.|::.|.||.|||.:||:|:||||||:.||||:|
  Rat   250 SFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIV 314

  Fly   320 VTIAVLNVNFRSPVTHRMAPWVQRLFIQILPKLLCIERPKKEEPEEDQPPEVLTDVYHLPPDVDK 384
            :|:.||||::|:|.||.|..||:.:|:.:||:::.:.||...|.:   .|:..|.......:::.
  Rat   315 ITVFVLNVHYRTPTTHTMPTWVKAVFLNLLPRVMFMTRPTSGEGD---TPKTRTFYGAELSNLNC 376

  Fly   385 FVNYDSKRFSGDYGIPALPASHRFDLAAAGGISAHCFAEPPLPSSLPLPGADDDLFSPSGLNGDI 449
            |...|||  |...|.|           ...|...:|.......|:          || :.|....
  Rat   377 FSRADSK--SCKEGYP-----------CQDGTCGYCHHRRVKISN----------FS-ANLTRSS 417

  Fly   450 SPGCCPAAAAAAAADLSPTFEKPYAREMEKTIEGSRFIAQHVKNKDKFESVEEDWKYVAMVLDRM 514
            |.....|..:.:|  |||        |:::.|:..::||:::|.::..:.:::||||||||:||:
  Rat   418 SSESVDAVLSLSA--LSP--------EIKEAIQSVKYIAENMKAQNVAKEIQDDWKYVAMVIDRI 472

  Fly   515 FLWIFAIACVVGTALIILQ 533
            |||:|.:.|::|||.:.||
  Rat   473 FLWVFILVCILGTAGLFLQ 491

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha1NP_001262916.1 Neur_chan_LBD 25..240 CDD:280998 109/216 (50%)
LIC 27..530 CDD:273305 229/504 (45%)
Neur_chan_memb 247..530 CDD:280999 115/282 (41%)
Chrna3NP_434692.2 LIC 24..490 CDD:273305 230/513 (45%)
Neur_chan_LBD 29..235 CDD:280998 109/216 (50%)
Neur_chan_memb 242..489 CDD:280999 115/283 (41%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 253 1.000 Domainoid score I1995
eggNOG 1 0.900 - - E1_KOG3645
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 477 1.000 Inparanoid score I1422
OMA 1 1.010 - - QHG45250
OrthoDB 1 1.010 - - D188416at33208
OrthoFinder 1 1.000 - - FOG0000583
OrthoInspector 1 1.000 - - mtm12327
orthoMCL 1 0.900 - - OOG6_101158
Panther 1 1.100 - - O PTHR18945
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X294
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1312.880

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