Protein Alignment nAChRalpha1 and Chrnb1

DIOPT Version :9

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_001382047.1
• Gene: Chrnb1 / 24261
• RGDID: 2349
• Length: 504
• Species: Rattus norvegicus
• Alignment Length: 570
• Identity: 201/570 - (35%)
• Similarity: 302/570 - (52%)
• Gaps: 115/570 - (20%)

  Fly     1 MGSVLFAAVFIALHFATGGLANPDAKRLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDV- 64
            :|::|.....:....|.|...:....:|...|.|:|:..:||.....||:.|.:||.|:|||.:
  Rat     3 LGALLLILGILGTPLAPGARGSEAEGQLLKKLFSDYDSSVRPAQEVGDRVGVSIGLTLAQLISLV 67

  Fly    65 --NLKNQIMTTNVWVEQEWNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMT 127
              |.|::.|:|.|:::.||.||:|.|:|.::.|:::|.|.:|.:||||:||.||.|||::|.:..
  Rat    68 RENEKDEEMSTKVYLDLEWTDYRLSWDPAEHDGIESLRVTAESVWLPDVVLLNNNDGNFDVALDI 132

  Fly   128 KAILHHTGKVVWKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIE 192
            ..::...|.|.|:||.:|:|.|.|.|.|||||.|.|.|.|.|::||...|.   ||...|.|
  Rat   133 NVVVSFEGSVRWQPPGLYRSSCSIQVTYFPFDWQNCTMVFSSYSYDSSEVS---LKTGPDPD--- 191

  Fly   193 VGIDLQDYYI-------SVEWDIMRVPA--------VRNEKFYSCCEEPYLDIVFNLTLRRKTLF 242
             |.:.|:.||       :.:|:|:..|:        .|..|     |....:::|.|.:|||.||
  Rat   192 -GQERQEIYIHEGTFIENGQWEIIHKPSRLIHLPGDRRGGK-----EGHREEVIFYLIIRRKPLF 250

  Fly   243 YTVNLIIPCVGISFLSVLVFYLPSDSGEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYL 307
            |.||:|.||:.|:.|::.|||||.|:|||:.|.|..||:||||.||||:.:|.|||.||::.|||
  Rat   251 YLVNVIAPCILITLLAIFVFYLPPDAGEKMGLSIFALLTLTVFLLLLADKVPETSLAVPIIIKYL 315

  Fly   308 LFTMMLVTLSVVVTIAVLNVNFRSPVTHRMAPWVQRLFIQILPKLLCIERPKKEEPEEDQPPEVL 372
            :|||:|||.||::::.|||::.|||.||:|..||:::||..||..|.::|||   ||.||.||..
  Rat   316 MFTMILVTFSVILSVVVLNLHHRSPHTHQMPFWVRQIFIHKLPPYLGLKRPK---PERDQLPEPH 377

  Fly   373 ------------TDVYHL--PPDVDKFVNYDSKRFSGDYGIPAL----PASHRFDLAAAGGISAH 419
                        ||.|.:  ||              .|:..|.|    |.|...||..
  Rat   378 HSFSPRSGWGRGTDEYFIRKPP--------------CDFLFPKLNRFQPESPAPDLRR------- 421

  Fly   420 CFAEPPLPSSLPLPGADDDLFSPSGLNGDISPGCCPAAAAAAAADLSPTFEKPYAREMEKTIEGS 484
             |.:.| |.::.||                                         :|:.:.|...
  Rat   422 -FIDGP-PRAVGLP-----------------------------------------QELREVISSI 443

  Fly   485 RFIAQHVKNKDKFESVEEDWKYVAMVLDRMFLWIFAIACVVGTALIILQA 534
            .::|:.::.::..::::|||::||||:||:|||.|.:...|||.:|.|.|
  Rat   444 SYMARQLQEQEDHDALKEDWQFVAMVVDRLFLWTFIVFTSVGTLVIFLDA 493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	Neur_chan_LBD	25..240	CDD:280998	84/232 (36%)
		LIC	27..530	CDD:273305	194/538 (36%)
		Neur_chan_memb	247..530	CDD:280999	104/300 (35%)
Chrnb1	NP_001382047.1	LGIC_ECD_nAChR_B1	27..248	CDD:349825	84/232 (36%)
		Neur_chan_memb	255..490	CDD:397193	104/301 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	365..384		9/21 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810