Protein Alignment nAChRalpha1 and Chrna9

DIOPT Version :10

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_001074573.1
• Gene: Chrna9 / 231252
• MGIID: 1202403
• Length: 479
• Species: Mus musculus
• Alignment Length: 543
• Identity: 199/543 - (36%)
• Similarity: 284/543 - (52%)
• Gaps: 92/543 - (16%)

  Fly    10 FIALHFATGGL-----ANPD-AKRLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLKN 68
            |..::||..|:     ||.. |::|:.||..:|:..:|||.:....|.|.:.:.|||:.|::.:|
Mouse    10 FCWMYFAASGIKAVETANGKYAQKLFSDLFEDYSNALRPVEDTDAVLNVTLQVTLSQIKDMDERN 74

  Fly    69 QIMTTNVWVEQEWNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKAILHH 133
            ||:|..:|:.|.|:|..|.|:.|.|.|:|::.:||:.:|.|||||||.||......:.|..:|.:
Mouse    75 QILTAYLWIRQTWHDAYLTWDRDQYDGLDSIRIPSDLVWRPDIVLYNKADDESSEPVNTNVVLRY 139

  Fly   134 TGKVVWKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEVGIDLQ 198
            .|.:.|..|||.||.|.:||.|||||.|.|.:.||||||:|..||:.:   ..||.      ||.
Mouse   140 DGLITWDSPAITKSSCVVDVTYFPFDSQQCNLTFGSWTYNGNQVDIFN---ALDSG------DLS 195

  Fly   199 DYYISVEWDIMRVPAVRNEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSVLVFY 263
            |:...|||::..:|||:|...|.||.|||.|:.|.|.|:|::.||.|||:||||.||||:.|.||
Mouse   196 DFIEDVEWEVQGMPAVKNVISYGCCSEPYPDVTFTLLLKRRSSFYIVNLLIPCVLISFLAPLSFY 260

  Fly   264 LPSDSGEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAVLNVN 328
            ||:.||||:||.::|||::|||.|::|||: |.|..|||:|||.:.||.|:|.|..:||.|:|::
Mouse   261 LPAASGEKVSLGVTILLAMTVFQLMVAEIM-PASENVPLIGKYYIATMALITASTALTIMVMNIH 324

  Fly   329 F----RSPVTHRMAPWVQRLFIQILPKLL--------CIERPKKEEPEEDQPPEVLTDVYHLPPD 381
            |    ..||.|    |.:.:.::.:.::|        |:      .|...|.||.:|.||...|.
Mouse   325 FCGAEARPVPH----WAKVVILKYMSRILFVYDVGESCL------SPRHSQEPEQITKVYGKLPG 379

  Fly   382 VDKFVNYDSKRFSGDYGIPALPASHRFDLAAAGGISAHCFAEPPLPSSLPLPGADDDLFSPSGLN 446
            .:                  |.||...||:          .:..|...|     .:||    |..
Mouse   380 SN------------------LKASRNKDLS----------RKKELRKLL-----KNDL----GYQ 407

  Fly   447 GDISPGCCPAAAAAAAADLSPTFEKPYAREMEKTIEGSRFIAQHVKNKDKFESVEEDWKYVAMVL 511
            |.|                 |.....|....|...:...:||:.:|:.....|...:||.||.|:
Mouse   408 GGI-----------------PQNTDSYCARYEALTKNIEYIAKCLKDHKATNSKGSEWKKVAKVI 455

  Fly   512 DRMFLWIFAIACVVGTALIILQA 534
            ||.|:|||.....|.|.|||.:|
Mouse   456 DRFFMWIFFAMVFVMTVLIIARA 478

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	LGIC_ECD_nAChR_proto_alpha-like	24..242	CDD:349832	91/218 (42%)
		LIC	27..530	CDD:455710	188/514 (37%)
		Cys-loop	149..163	CDD:349832	9/13 (69%)
Chrna9	NP_001074573.1	LIC	10..474	CDD:455710	195/537 (36%)
		LGIC_ECD_nAChR_A9	31..237	CDD:349823	91/214 (43%)
		Cys-loop	155..169	CDD:349823	9/13 (69%)