Protein Alignment nAChRalpha1 and HTR3D

DIOPT Version :9

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_001157118.1
• Gene: HTR3D / 200909
• HGNCID: 24004
• Length: 454
• Species: Homo sapiens
• Alignment Length: 380
• Identity: 86/380 - (22%)
• Similarity: 149/380 - (39%)
• Gaps: 80/380 - (21%)

  Fly    38 RLIRPVGNNSDRLTVKMGLRLSQLIDVNLKNQIMTTNVWVEQEWNDYKLKWNPDDYGGVDTLHVP 102
            :.|.||.|.|....|.:...||.:  .|..::|.|.|....:.|::..::||||:.||:....:.
Human    51 KAIGPVTNYSVATHVNISFTLSAI--WNCYSRIHTFNCHHARPWHNQFVQWNPDECGGIKKSGMA 113

  Fly   103 SEHIWLPDIVLYNNADGNYEVTIMTKAILHHTGKVV----WK-----PPAIYKSFCEIDV----- 153
            :|::||.|:.:..:.|......:.:.:|:..|...:    |.     .|:|..|......
Human   114 TENLWLSDVFIEESVDQTPAGLMASMSIVKATSNTISQCGWSASANWTPSISPSMDRARAWRRMS 178

  Fly   154 EYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEVGIDLQDYYISVEWDIMRVPAVRNEK 218
            ..|....:|.|.....|...|  :..|.:|.|..::..|..|    :::          |:|..
Human   179 RSFQIHHRTSFRTRREWVLLG--IQKRTIKVTVATNQYEQAI----FHV----------AIRRR- 226

  Fly   219 FYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSVLVFYLPSDSGEKISLCISILLSLT 283
               |...||:                ||.::|...:..:..|.||||.:||......:::||..:
Human   227 ---CRPSPYV----------------VNFLVPSGILIAIDALSFYLPLESGNCAPFKMTVLLGYS 272

  Fly   284 VFFLLLAEIIPPT------SLTVPL--------LGKYLLFTMMLVTLSVVVTIAV---LNVNFRS 331
            ||.|::.:::|.|      ||..||        .|.|....:.|:..|::.||.:   |:|....
Human   273 VFLLMMNDLLPATSTSSHASLVAPLALMQTPLPAGVYFALCLSLMVGSLLETIFITHLLHVATTQ 337

  Fly   332 PVTHRMAPWVQRLFIQILPKLLCIERPKKEEPEEDQPPEVLTDVYHLP----PDV 382
            |:.  :..|:..|.:....:..|.    ...|::......||.. |||    |:|
Human   338 PLP--LPRWLHSLLLHCTGQGRCC----PTAPQKGNKGPGLTPT-HLPGVKEPEV 385

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	Neur_chan_LBD	25..240	CDD:280998	45/215 (21%)
		LIC	27..530	CDD:273305	86/380 (23%)
		Neur_chan_memb	247..530	CDD:280999	39/157 (25%)
HTR3D	NP_001157118.1	Neur_chan_LBD	55..>130	CDD:280998	22/76 (29%)
		LIC	92..452	CDD:273305	74/337 (22%)
		Neur_chan_memb	237..>351	CDD:280999	30/115 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	363..410		8/24 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810