Protein Alignment nAChRalpha1 and acr-23

DIOPT Version :9

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_504024.2
• Gene: acr-23 / 191606
• WormBaseID: WBGene00000062
• Length: 545
• Species: Caenorhabditis elegans
• Alignment Length: 589
• Identity: 163/589 - (27%)
• Similarity: 267/589 - (45%)
• Gaps: 124/589 - (21%)

  Fly     9 VFIALHFATGGLANPDAKRLYD---DLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLKNQI 70
            :||: ..|.|...|||....|:   :::.||.:.:.|.......:.|.:.|:|.|:|.||...|.
 Worm     9 IFIS-QLALGLSNNPDIPIQYELANNIMENYQKGLIPKVRKGSPINVTLSLQLYQIIQVNEPQQY 72

  Fly    71 MTTNVWVEQEWNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVT-IMTKAILHHT 134
            :..|.|..:.|.|..|.|:|.::.....:....:.|||||..|||:.:.:...: .:|...|...
 Worm    73 LLLNAWAVERWVDQMLGWDPSEFDNETEIMARHDDIWLPDTTLYNSLEMDDSASKKLTHVKLTTL 137

  Fly   135 GK-----VVWKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEVG 194
            ||     |....|.|||..|.::::|||||.|||.|.||||::|..::|  :..:|..:.    .
 Worm   138 GKNQGAMVELLYPTIYKISCLLNLKYFPFDTQTCRMTFGSWSFDNSLID--YFPRTFTNG----P 196

  Fly   195 IDLQDYYISVEWDIMRVPAVRNEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSV 259
            |.|.::..:..|.::.....|.||.|:||...|..:.:::.::||.|:|.:|||.|...|:|:|:
 Worm   197 IGLANFLENDAWSVLGTKVNREEKKYTCCPVNYTLLHYDVVIQRKPLYYVLNLIAPTAVITFISI 261

  Fly   260 LVFYLP----------SDS-----GEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLF 309
            :.|:..          |.|     .|||:|.|:.|||:::...::::.:|.||..|||:.   ||
 Worm   262 IGFFTSVNPFTNFCNVSSSVHDLRQEKITLGITTLLSMSIMIFMVSDKMPSTSTCVPLIA---LF 323

  Fly   310 TMMLVTLSVVVTIAVLNVNFRSPV--------------THRMAPWVQRLFIQ--ILPKLLCIERP 358
            ..:::|:..|.|:|..:|.|...:              |||:||:|   .||  ::.|....:|.
 Worm   324 YTLMITIISVGTLAASSVIFVQKLGSIGNPPASKTMKWTHRIAPFV---LIQMPLVMKQAYAKRA 385

  Fly   359 KKEEPEE--DQPPEVLTDVYHLPPD-----------------VDKFVNYDSKRFSGDYGIPALPA 404
            |:|:..:  .:...:.|.||||..|                 :..|.|.|    .|:...|.:..
 Worm   386 KEEKHRKRMSRKNSMWTKVYHLARDHSKLMETVPDGAVKFNQISDFKNND----IGNMESPRMAE 446

  Fly   405 SHRFDLAAAGGISAHCFAEPPLPSSLPLPGADDDLFSPSGLNGDISPGCCPAAAAAAAADLSPTF 469
            |...:..||           |:.:|.     .:.|..|. ||.       .|::.:..:.|.||
 Worm   447 SQTSETFAA-----------PMDTSF-----TESLHIPE-LNR-------VASSNSIQSVLKPT- 486

  Fly   470 EKPYAREMEKTIEGSRFIAQHVKNKDKFESVEEDWKYVAMVLDRMFLWIFAIACVVGTALIILQA 534
                  |::.|...:|.|            ||.:|.:||.||:|:||..|.| |.:.:|:.|
 Worm   487 ------EIQLTPYCTRNI------------VELEWDWVAAVLERVFLIFFTI-CFLFSAIGI--- 529

  Fly   535 PSLY 538
             :||
 Worm   530 -NLY 532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	Neur_chan_LBD	25..240	CDD:280998	64/223 (29%)
		LIC	27..530	CDD:273305	153/561 (27%)
		Neur_chan_memb	247..530	CDD:280999	85/332 (26%)
acr-23	NP_504024.2	Neur_chan_LBD	27..242	CDD:280998	64/220 (29%)
		Neur_chan_memb	249..529	CDD:280999	85/333 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910