Protein Alignment nAChRalpha1 and acr-19

DIOPT Version :9

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_001129756.1
• Gene: acr-19 / 191605
• WormBaseID: WBGene00000058
• Length: 560
• Species: Caenorhabditis elegans
• Alignment Length: 561
• Identity: 182/561 - (32%)
• Similarity: 283/561 - (50%)
• Gaps: 81/561 - (14%)

  Fly    26 KRLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLKNQIMTTNVWVEQEWNDYKLKWNP 90
            :|||..|..|||:|.|||.|.|:.:.|.:|:...|::|::.|:|||.:|||:...|.|:.|.|:|
 Worm    32 RRLYAKLAENYNKLARPVRNESEAVVVLLGMDYQQILDIDEKHQIMNSNVWLRMSWTDHYLTWDP 96

  Fly    91 DDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKAILHHTGKVVWKPPAIYKSFCEIDVEY 155
            .::|.:..:.:|..:||.||::|||:.|..::.|....|::.:||.|.|.||||.:|.|.||:.|
 Worm    97 SEFGNIKEVRLPINNIWKPDVLLYNSVDQQFDSTWPVNAVVLYTGNVTWIPPAIIRSSCAIDIAY 161

  Fly   156 FPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEVGIDLQDYYISVEWDIMRVPAVRNEKFY 220
            ||||.|.|.||||||||.|:..||           |...|....|..:.||:::.:.:.|:..||
 Worm   162 FPFDTQHCTMKFGSWTYSGFFTDL-----------INTTISPATYKPNGEWELLGLTSQRSIFFY 215

  Fly   221 SCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSVLVFYLPSDSGEKISLCISILLSLTVF 285
            .||.|||.|:.|.:::||:||:|..||::||:.||.|::|.|.||:|.|||::|.::|.:||.||
 Worm   216 ECCPEPYYDVTFTVSIRRRTLYYGFNLLLPCMLISSLALLSFTLPADCGEKLNLGVTIFMSLCVF 280

  Fly   286 FLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAVLNVNFRSPVTHR-MAPWVQRLFIQIL 349
            .:::||.:|.||..:||:..|....|..|..|||.|:..||.:.|||..:: |..:::.|.:..|
 Worm   281 MIMVAEAMPQTSDALPLIQIYFSCIMFQVGASVVATVIALNFHHRSPEQYKPMNKFLKTLLLGWL 345

  Fly   350 PKLLCIERPKKEEPEEDQPPEVLTDVYHLPPDVDKFVNYDSKRFSGDY---------------GI 399
            |.||.:|||               ||..|......:.: |:|:....|               |.
 Worm   346 PTLLGMERP---------------DVLELSVHGAHYAS-DNKKKQRQYLIEVERHILTRPNGNGH 394

  Fly   400 PALPASHRFDLAAAGGISAHCFAEPPLPS------------SLP---LPGADDDLFS-------- 441
            .|:..:...||:..   :.|..|:...||            .||   :.||.|...:
 Worm   395 SAVDKAVHLDLSTG---NPHSDAKKSSPSPKRTSASIMGMTGLPTTQMNGALDSSINKYTCTKVT 456

  Fly   442 ------PSGLNGDISPGCCPA---AAAAAAADLSPTFEKPYAREMEKTIEGSRFIAQHVKNKDKF 497
                  .:.:|...||...|.   .....|.:....||.   |.....:...|.|:..|:.::..
 Worm   457 RPLENGSATINHKSSPQINPINNNNIYKCANNQKTQFED---RHFHHILNELRVISARVRKEEAM 518

  Fly   498 ESVEEDWKYVAMVLDRMFLWIFAIACVVGTALIILQAPSLY 538
            .:::.||.:.:.|:||:....|:....:.||:|...||.|:
 Worm   519 HALQADWMFASRVVDRVCFLAFSAFLFMCTAIISYNAPHLF 559

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	Neur_chan_LBD	25..240	CDD:280998	88/213 (41%)
		LIC	27..530	CDD:273305	178/550 (32%)
		Neur_chan_memb	247..530	CDD:280999	86/330 (26%)
acr-19	NP_001129756.1	LIC	31..548	CDD:273305	176/548 (32%)
		Neur_chan_LBD	31..235	CDD:280998	88/213 (41%)
		Neur_chan_memb	242..>354	CDD:280999	46/111 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910