Protein Alignment nAChRalpha1 and acr-18

DIOPT Version :10

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_506868.2
• Gene: acr-18 / 191604
• WormBaseID: WBGene00000057
• Length: 510
• Species: Caenorhabditis elegans
• Alignment Length: 535
• Identity: 142/535 - (26%)
• Similarity: 245/535 - (45%)
• Gaps: 83/535 - (15%)

  Fly    16 ATGGLANPDAKRLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLKNQIMTTNVWVEQE 80
            ||...|....:.||:.|..:|.:.||||.|.|:.|.|::...|.|::.|:.::||:....|:|..
 Worm    21 ATSHPARTPMRNLYEHLFLDYVKEIRPVRNESESLKVEIKFWLKQILKVDERDQIVNIYCWLELY 85

  Fly    81 WNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIM-TKAILHHTGKVVWKPPAI 144
            |.|..|.|:|..:|.:..:|||:..||.||:::||||:.|.|...| |.||:.:||:|:.....|
 Worm    86 WIDETLTWDPKKFGNLSRIHVPAHKIWKPDVLVYNNANMNVEENEMETNAIVDNTGRVMLFRSMI 150

  Fly   145 YKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEVGIDLQDYYISVEWDIM 209
            ....|.::::.||||:|.||:.|.||:.||..:|   |..|..:||:|:      |..:.||.:.
 Worm   151 TDISCNLNLQQFPFDQQICFVTFASWSMDGSKLD---LSATPKTDNLEL------YIRNTEWGLT 206

  Fly   210 RVPAVRNEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSVLVFYLP----SDSGE 270
            .......:|.|.||..|:.|:.:.:.|||...:|..:|:||...|:.::::.|:.|    .::.|
 Worm   207 DFRVKIYQKIYDCCPHPFPDVTYFMVLRRSPSYYIFSLVIPSAFITVVTIVGFFTPHSTTGENTE 271

  Fly   271 KISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAVLNVNFRSPVTH 335
            |:||.::.|||:.:..:::::.:|.||..:||:|||.:..:.|:.::...|...|:...|.....
 Worm   272 KVSLGVTALLSMAIIMMMVSDEVPATSEVIPLIGKYYIGLIFLIFMAAFTTTLTLSYQMRGNSGQ 336

  Fly   336 RMAPWVQRLFIQILPKLLCI------ERPKK--EEPEEDQPPEVLTDVYHLPPDVDKFVNYDSKR 392
            .:.|.|:..|...:....||      :.|||  ......|.........|        ||..||
 Worm   337 EVDPRVRDFFFYQIAANPCISWAFSFQLPKKLLRSDHRKQSFFFTNGAAH--------VNGYSK- 392

  Fly   393 FSGDYGI--PALPASH---RFDLAAAGGISAHCFAEPPLPSSLPLPGADDDLFSPSGLNGDISPG 452
                 |.  |..|.:|   ..::...|.:.:...::
 Worm   393 -----GALHPNTPPAHIVKMEEITGGGSVKSFVMSQ----------------------------- 423

  Fly   453 CCPAAAAAAAADLSPTFEKPYAREMEKTIEGSRFIAQHVKNKDKFESVEEDWKYVAMVLDRMFLW 517
              .:||.:.....|....|....:|:.:|...|.:     .:.|||     |:.|..::||..::
 Worm   424 --ESAATSTLLTSSLMKIKVVLDDMKASIHAEREL-----KRIKFE-----WQQVTRLIDRCIMF 476

  Fly   518 IFAIACVVGTALIIL 532
            .: |...:..|:::|
 Worm   477 SY-ILITIAFAMVML 490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	LGIC_ECD_nAChR_proto_alpha-like	24..242	CDD:349832	77/218 (35%)
		LIC	27..530	CDD:455710	138/520 (27%)
		Cys-loop	149..163	CDD:349832	6/13 (46%)
acr-18	NP_506868.2	LGIC_ECD_nAChR	55..235	CDD:349798	65/188 (35%)
		Cys-loop	155..169	CDD:349798	6/13 (46%)
		LGIC_TM_cation	238..>327	CDD:349853	24/88 (27%)
		TM1 helix	238..262	CDD:349853	6/23 (26%)
		Neur_chan_memb	244..486	CDD:460753	59/297 (20%)
		TM2 helix	274..295	CDD:349853	5/20 (25%)
		TM3 helix	306..327	CDD:349853	4/20 (20%)