Protein Alignment nAChRalpha1 and acr-17

DIOPT Version :9

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_001023961.1
• Gene: acr-17 / 191603
• WormBaseID: WBGene00000056
• Length: 515
• Species: Caenorhabditis elegans
• Alignment Length: 576
• Identity: 158/576 - (27%)
• Similarity: 268/576 - (46%)
• Gaps: 104/576 - (18%)

  Fly    11 IALHFATGGLANPDAKRLYDDLLSNYNRLIRPVGNNSDRLT-VKMGLRLSQLIDVNLKNQIMTTN 74
            :.|||.. |||....|:|...|..:|::.:|||.:.|...| |.:.|...|:..|:..:||:|..
 Worm    11 VVLHFLM-GLAMAQQKQLIKYLFRDYHKELRPVKDESSGPTNVTVQLYFKQIQKVHENDQIITLY 74

  Fly    75 VWVEQEWNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNY-EVTIMTKAILHHTGKVV 138
            .|:|:.|.|..|.|||.|:|.:.:||||||.||.||:::||||:.|. |..:.|...:.||||:.
 Worm    75 CWIEEYWQDEFLTWNPSDFGNIKSLHVPSEMIWKPDLLVYNNANMNIKENEMQTNVQIEHTGKIS 139

  Fly   139 WKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTAD-------SDNIEVGID 196
            .....|....|::.:|.||:|:|.||:...||:|||..:.|...:|..:       :.|:.:
 Worm   140 LFRAIITDITCDLQMEKFPYDQQICFIMLASWSYDGSQIMLNTAEQPTEAPLDIKNTTNLAI--- 201

  Fly   197 LQDYYISVEWDIMRVPAVRNEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSVLV 261
            |..|..::||.::......|.|:|.||..||.||.:...::|...:|...||||...|:.::|:.
 Worm   202 LNHYIPNMEWKLVDFRYRNNLKYYDCCPNPYPDISYFFAIKRNPSYYLFTLIIPSAFITIVTVIG 266

  Fly   262 FYLP-SDSG---EKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKY---LLFTMMLVTLSVV 319
            |:.| |.:|   ||:||.::.||||.:..:::::.:|.||.:|||||:|   |:|.|.|.|....
 Worm   267 FFTPHSSTGENTEKVSLGVTALLSLAIILMMVSDKLPATSNSVPLLGQYYIGLIFIMFLATYCTT 331

  Fly   320 VTIAV-LNVNFRSPVTHRMAPWVQRLFIQILPKLLCIERPK---------KEEPEEDQPPEVLTD 374
            .|:.: :..|...|:|.|:     |.|      ||.|...:         :|.....:..::...
 Worm   332 FTLGIQMQGNAGRPITRRL-----RSF------LLSIRMNRNSFVQWFFGRELMNTQESIKMRLK 385

  Fly   375 VYHLPPDVDK-----FVNYDSKRFSGDYGIPALPASHRFDLAAAGGISAHCFAEPPLPSSLPLPG 434
            .|....::.|     ||.:..|....|.     |..::         :|....:..:.||
 Worm   386 KYDKLSELKKKFANGFVQFQQKLLKTDE-----PKHNK---------TASLIEQESIDSS----- 431

  Fly   435 ADDDLFSPSGLNGDISPGCCPAAAAAAAADLSPTFEKPYAREMEKTIEGSRFIAQHVKNKDKFES 499
               .|..|:..|              ...|:               :...:.|.|.:.:::..:.
 Worm   432 ---KLLDPAMYN--------------VVVDV---------------LSSVQSIRQDLTSQEHLKR 464

  Fly   500 VEEDWKYVAMVLDRMFLWIFAIACVVGTALIILQAPSLYDQSQPIDILYSKIAKKK 555
            :.::|:.:|.:|:::.:|||.|:.|...:.:      |||...| .|:.:::.:.|
 Worm   465 IRKEWQMLARMLEKIIMWIFIISTVAFASFM------LYDTQDP-PIITNEVMRSK 513

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	Neur_chan_LBD	25..240	CDD:280998	78/223 (35%)
		LIC	27..530	CDD:273305	145/533 (27%)
		Neur_chan_memb	247..530	CDD:280999	67/304 (22%)
acr-17	NP_001023961.1	LIC	23..491	CDD:273305	146/532 (27%)
		Neur_chan_LBD	24..245	CDD:280998	78/223 (35%)
		Neur_chan_memb	252..491	CDD:280999	67/300 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910