Protein Alignment nAChRalpha1 and acr-15

DIOPT Version :10

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_505206.2
• Gene: acr-15 / 191602
• WormBaseID: WBGene00000054
• Length: 479
• Species: Caenorhabditis elegans
• Alignment Length: 551
• Identity: 157/551 - (28%)
• Similarity: 259/551 - (47%)
• Gaps: 100/551 - (18%)

  Fly    11 IALHF---ATGGLANPDAKRLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLKNQIMT 72
            |.|||   .|....:|...||.:||:|.|.|..||..::|..:.|.:|:.|.|:|:::.|.:.:.
 Worm     5 ILLHFLLLITQLNGSPAEVRLINDLMSGYVREERPTLDSSKPVVVSLGVFLQQIINLSEKEEQLE 69

  Fly    73 TNVWVEQEWNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKAILHHTGKV 137
            .|.|::.:|.|..|:|.|..|..|..|..|.:.:|.|||:|||:.|..::.:.....:.:|||.:
 Worm    70 VNAWLKFQWRDENLRWEPTAYENVTDLRHPPDALWTPDILLYNSVDSEFDSSYKVNLVNYHTGNI 134

  Fly   138 VWKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEVG-IDLQDYY 201
            .|.||.|:|..|::|:.:||||||.|:.|||||||            |.|...:|.| .|..::.
 Worm   135 NWMPPGIFKVSCKLDIYWFPFDEQVCYFKFGSWTY------------TRDKIQLEKGDFDFSEFI 187

  Fly   202 ISVEWDIMRVPAVRNEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSVLVFYLPS 266
            .:.||.|:........|.|.||.|.|.||.|.|.|||:||:|:.|||.|.:....|.:|.|.:..
 Worm   188 PNGEWIIIDYRTNITVKQYECCPEQYEDITFTLHLRRRTLYYSFNLIAPVLLTMILVILGFTVSP 252

  Fly   267 DSGEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAVLNVNFRS 331
            ::.||:.|.||:.|::.:|..:::|:.|.||..|||||.:......:..|:...|:.|.:.:||:
 Worm   253 ETCEKVGLQISVSLAICIFLTIMSELTPQTSEAVPLLGVFFHTCNFISVLATSFTVYVQSFHFRN 317

  Fly   332 PVTH-RMAPWVQRLFIQILPKLLCIERPKKEEPEEDQPPEVLTDVYHLPPDVDKFVNYD--SKRF 393
            ...| ||..|::.:.::..|.||.::.|.:|.                        |:.  ::.:
 Worm   318 QHVHERMDFWMRFILLEWSPWLLRMKMPDREN------------------------NFQTLTESW 358

  Fly   394 SGDYGIPALPASHRFDLAAAGGISAHCFAEPPLPSSLPLPGADDDLFSPSGLNGDISPGCCPAAA 458
            .|        .:.|..:|.    :|..:|:.|:..           ....|:.
 Worm   359 KG--------RNRRESMAR----TAFEYADGPVTQ-----------IHSMGIM------------ 388

  Fly   459 AAAAADLSPTFEK----------------PYAREMEKTIEGSRFIAQHVKNKDKFESVEEDWKYV 507
                  |...||:                ...|.::|..:..:.|.:|..:.|:...|..:|::.
 Worm   389 ------LKDNFEELIYQVKQEKIADEKGIERLRVLQKIYDHVKMIREHDDDNDEDSRVALEWRFA 447

  Fly   508 AMVLDRMFLWIFAIACVVGTALIILQAPSLY 538
            |:|:||:.|..|::..||.:.:|.|:||.|:
 Worm   448 AIVVDRLCLLAFSLLIVVVSIIIALRAPYLF 478

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	LGIC_ECD_nAChR_proto_alpha-like	24..242	CDD:349832	81/218 (37%)
		LIC	27..530	CDD:455710	146/522 (28%)
		Cys-loop	149..163	CDD:349832	8/13 (62%)
acr-15	NP_505206.2	LIC	19..470	CDD:455710	147/527 (28%)
		LGIC_ECD_nAChR	47..225	CDD:349798	69/189 (37%)
		Cys-loop	146..160	CDD:349798	8/13 (62%)