Protein Alignment nAChRalpha1 and lev-8

DIOPT Version :10

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_509932.2
• Gene: lev-8 / 191600
• WormBaseID: WBGene00002975
• Length: 531
• Species: Caenorhabditis elegans
• Alignment Length: 588
• Identity: 199/588 - (33%)
• Similarity: 314/588 - (53%)
• Gaps: 89/588 - (15%)

  Fly     3 SVLFAAVFIALHFATGGLANPDAKRLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLK 67
            |.:|..|...||..|.. ||....:|.::||::||:.:|||.|.||.|.||.|..|.:||||:..
 Worm     8 SHIFLLVIFILHIVTIN-ANKHVSQLLENLLTDYNKAVRPVHNASDALKVKFGANLCRLIDVDEV 71

  Fly    68 NQIMTTNVWVEQEWNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKAILH 132
            ||::||::|:|.:|.|.||.|||.|:|||:.:|:||:.||:|||||||||||...:||.:.|.:.
 Worm    72 NQVLTTSLWLEMQWYDKKLTWNPTDWGGVEYIHIPSDQIWIPDIVLYNNADGEPHITITSLAKID 136

  Fly   133 HTGKVVWKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNI------ 191
            |.|:|||:||:||||||.|:::|||:|.|||.||||.|:.||..:||..:  ..|.|:|
 Worm   137 HHGRVVWQPPSIYKSFCPINIKYFPYDWQTCEMKFGGWSNDGETLDLYQI--PVDVDDIPQVKRQ 199

  Fly   192 ---------EVGIDLQDYYISVEWDIMRVPAVRNEKFY-SCC-EEPYLDIVFNLTLRRKTLFYTV 245
                     |.|:.|..|:.|.|||::...:.|..:.| .|| ::.|:||.:.:.:|||.:|:||
 Worm   200 DDGVEFLYLEKGLGLSFYHESAEWDLLSATSSRYAQIYPGCCGQQYYIDIKYRIIIRRKAIFFTV 264

  Fly   246 NLIIPCVGISFLSVLVF-YLPSDSGEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLF 309
            .|.|||:.|:.::..|| .||::  .|::..||:|::.:||:|:|.::||||||::.|:|.||||
 Worm   265 TLTIPCMLIANVTPFVFLILPNE--HKMTYSISVLVAFSVFYLVLIDLIPPTSLSLSLIGIYLLF 327

  Fly   310 TMMLVTLSVVVTIAVLNVNFRSPVTHRMAPWVQRLFIQILPKLLCIERPK----KEEPEEDQPPE 370
            |:::|::|:::::..:|:..:...:..|:.|.:.||:|.|||||.::..:    .:|..|...|.
 Worm   328 TLLMVSVSIILSVVTINMYRKQAFSSGMSHWQRWLFVQRLPKLLRLKTLEHTLGPDEGSETTTPR 392

  Fly   371 VLTDVYHLPPDVDKFVNYDSKRFSGDYGIPALPASHRFDLAAAGGISAHCFAEPPLPSSLPLPGA 435
                                   :|...:.|.......:                       |..
 Worm   393 -----------------------TGSVSVTASVTQRTLN-----------------------PNN 411

  Fly   436 DDDLFSPSGLNGDISPGCCPAAAAAAAADLSPTFEKPYAREMEKTIEGS-RFIAQHVKNKDKFES 499
            :..:|.|..|..........|.....|||....|.|         |.|. :.|:.|..|:.....
 Worm   412 NSPVFPPQRLRLLSLVQMDEALKQRCAADNLDLFRK---------IAGHLKIISAHFHNQQMEGK 467

  Fly   500 VEEDWKYVAMVLDRMFLWIFAIACVVGTALIILQAPSLYDQSQPIDILYSKIAKKKFELLKMGSE 564
            :.|:|:.:::|:||:||.:|....:....:.:..:|:|:|....   |...:|.|.   |..|:.
 Worm   468 ITEEWQLMSLVIDRIFLILFLAVSMAANIMFVYNSPTLFDDRPS---LVPSVAHKP---LSGGTI 526

  Fly   565 NTL 567
            |.|
 Worm   527 NVL 529

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	LGIC_ECD_nAChR_proto_alpha-like	24..242	CDD:349832	107/234 (46%)
		LIC	27..530	CDD:455710	181/525 (34%)
		Cys-loop	149..163	CDD:349832	7/13 (54%)
lev-8	NP_509932.2	LIC	10..499	CDD:455710	188/548 (34%)
		LGIC_ECD	31..261	CDD:475126	107/231 (46%)