Protein Alignment nAChRalpha1 and acr-10

DIOPT Version :9

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_508692.3
• Gene: acr-10 / 191598
• WormBaseID: WBGene00000049
• Length: 557
• Species: Caenorhabditis elegans
• Alignment Length: 550
• Identity: 172/550 - (31%)
• Similarity: 283/550 - (51%)
• Gaps: 66/550 - (12%)

  Fly    27 RLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLKNQIMTTNVWVEQEWNDYKLKWNPD 91
            :||.|:|..|.:|.|||....:.|.|.|.:.|.|:::::.:|||:..|.|::..|.||:|:|:|.
 Worm    29 KLYRDILQGYLKLARPVRYPRNVLKVHMKVFLQQILNLDGQNQIIEVNAWLKYVWMDYRLQWDPL 93

  Fly    92 DYGGVDTLHVP--SEHIWLPDIVLYNNADGNYEVTIMTKAILHHTGKVVWKPPAIYKSFCEIDVE 154
            .|..:.::...  ...||.|||:|||:|..:::.:..:..::::||:|.|.||.|:::.|::|:.
 Worm    94 QYDNITSIRFAGGENQIWRPDILLYNSASEDFDSSFKSNEVVYNTGEVNWIPPGIFRASCKMDIT 158

  Fly   155 YFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEVGIDLQDYYISVEWDIMRVPAVRNEKF 219
            |||||:|.|::|||||||.|..:||..:   |:.|:.|:.|||..|..|.||.:.:.|||::.|:
 Worm   159 YFPFDDQVCYLKFGSWTYHGLALDLSII---AEEDDSELSIDLSTYTPSGEWHLTKAPAVKDVKY 220

  Fly   220 YSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSVLVFYLPS-DSGEKISLCISILLSLT 283
            .|||:|||..:.|.:.|||:||||..|:|:|.:.||.::::.|.||: |..|||....:||||:.
 Worm   221 NSCCKEPYSTVTFYMFLRRRTLFYLFNIILPSLLISIMTLMGFCLPAHDMSEKIGYQTTILLSIC 285

  Fly   284 VFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAVLNVNFRSPVTHRMAPWVQRLFIQI 348
            .|..:::|:.||||.:|||||.:.....::.::|...||.|||..:|......|.|...::|:..
 Worm   286 FFVTIVSEMTPPTSESVPLLGMFFSSLTLISSVSTAFTITVLNFRYRQVQNIHMHPIFYKVFLIW 350

  Fly   349 LPKLLCIERP----KKEEPEEDQPPEVL------TDVYHLPPDVDKFVNYDSKRFSGDYGIP--- 400
            :|.||.::||    ||.........|:.      .|....||:.|..::.||   :....:|
 Worm   351 IPWLLLMKRPGVFYKKRRATVQAREEISFFDNGDDDCCPKPPEFDYSLSIDS---ADTLPLPPRP 412

  Fly   401 --------ALPASH-RFDLAAAGGISAHCFAEPPLPSSLPLPGADDDLFSPSGLNGDIS------ 450
                    ::||.| ..|.....||               |......|.....:|...|
 Worm   413 KPLLKKMHSVPAEHLHLDRKVGDGI---------------LKSQRRPLVLTKNVNKSHSLRSRRF 462

  Fly   451 -------PGCCPAAAAAAAADLSPTFEK---PYAREMEKTIEGSRFIAQHVKNKDKFESVEEDWK 505
                   ..|...|.....:..| |:..   .|.|::::.:   :.:.:.:..:.|:...:||||
 Worm   463 TQFEKYIKKCIDDAKLRKNSTYS-TYSMMIITYYRQIDEML---KLLNRRLDKQRKYLFKQEDWK 523

  Fly   506 YVAMVLDRMFLWIFAIACVVGTALIILQAP 535
            :.||.|||:.|.:..:..|:....:||..|
 Worm   524 FAAMALDRLCLLLITLLIVMCLFGMILSTP 553

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	Neur_chan_LBD	25..240	CDD:280998	85/214 (40%)
		LIC	27..530	CDD:273305	169/543 (31%)
		Neur_chan_memb	247..530	CDD:280999	79/321 (25%)
acr-10	NP_508692.3	Neur_chan_LBD	27..241	CDD:280998	85/214 (40%)
		Neur_chan_memb	248..>361	CDD:280999	40/112 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910