Protein Alignment nAChRalpha1 and acr-9

DIOPT Version :9

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_510285.2
• Gene: acr-9 / 191597
• WormBaseID: WBGene00000048
• Length: 534
• Species: Caenorhabditis elegans
• Alignment Length: 553
• Identity: 192/553 - (34%)
• Similarity: 291/553 - (52%)
• Gaps: 60/553 - (10%)

  Fly    11 IALHFATGGLANPDAKRLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLKNQIMTTNV 75
            :..|..|...::.|..||..||..||:...|||.|.|:.|.|.:.:.|.|::||:.|||::|...
 Worm    14 VLFHLLTEVHSSADEYRLLADLRHNYDPYERPVANASEPLVVSVKIYLQQILDVDEKNQVITLVA 78

  Fly    76 WVEQEWNDYKLKWNPDDYGGVDTLHVP--SEHIWLPDIVLYNNADGNYEVTIMTKAILHHTGKVV 138
            |:|.:|.||||||:|.:|||:..:.:|  :..||.||::|||:||.|::.|.....::.:||.|:
 Worm    79 WIEYQWTDYKLKWDPSEYGGIKDIRIPGNANAIWKPDVLLYNSADENFDSTYPVNYVVSYTGDVL 143

  Fly   139 WKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNI-EVGIDLQDYYI 202
            ..||.|.|..|:||:.|||||:|.|.:|||||||.|..:|||  ....:..|| :.|||:|.|..
 Worm   144 QVPPGILKLSCKIDITYFPFDDQICHLKFGSWTYSGNFIDLR--INGPEGKNISDEGIDVQYYVQ 206

  Fly   203 SVEWDIMRVPAVRNEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSVLVFYLPSD 267
            :.||:::.|||......:.  |:||..:.|.|.::|:||:|.:|||||...||.::||.|.||.|
 Worm   207 NGEWNLLAVPARHETNIFD--EQPYPSLFFYLIIQRRTLYYGLNLIIPSFLISLMTVLGFTLPPD 269

  Fly   268 SGEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAVLNVNFRSP 332
            :||||:|.|:||||:..|..::|::.||||..|||:|.:....|::|:.|||.|:.|||::.|.|
 Worm   270 AGEKITLEITILLSVCFFLSMVADMTPPTSEAVPLIGAFFSCCMLVVSASVVFTVLVLNLHNRKP 334

  Fly   333 VTHRMAPWVQRLFIQILPKLLCIERP----------KKEEPEEDQP---------PEVLTDVYHL 378
            .||.|:|:::.|.:..||.||.:.||          |.|:.||...         |...||..|.
 Worm   335 ETHEMSPFLRELLLIWLPWLLLMRRPGKTIFNCTHLKAEKAEEKAKQGSIKNGVGPGKPTDSVHP 399

  Fly   379 PPDVDKFVNYDSKRFSGDYGIPALPASHRFDLAAAGGISAHCFAEPPLPSSLPLPGADDDLFSPS 443
            ...:....|....|..      .:...:.|.:       .|....|..||.:          :|.
 Worm   400 SEGLSLMKNIKLGRQQ------TIDFEYEFHV-------QHNHLMPVAPSEM----------TPR 441

  Fly   444 GLNGDISPGCCPAAAAAAAADLSPTFEKPYAR----EMEKTIEGSRFIAQHVKNKDKFESVEEDW 504
            .....:       .|.:...|:..|....|.:    |::.....:|.:.:.::..::.|....||
 Worm   442 VTYSKV-------MAESYVEDVVMTELNKYMQKACLELKNISSQTRAMRKKMEEDERDEQAANDW 499

  Fly   505 KYVAMVLDRMFLWIFAIACVVGTALIILQAPSL 537
            |:.|||:||..|..|::..||.|..|:..:|.|
 Worm   500 KFAAMVVDRCCLITFSVFIVVSTCGIMFSSPHL 532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	Neur_chan_LBD	25..240	CDD:280998	92/217 (42%)
		LIC	27..530	CDD:273305	186/528 (35%)
		Neur_chan_memb	247..530	CDD:280999	90/305 (30%)
acr-9	NP_510285.2	LIC	28..525	CDD:273305	186/530 (35%)
		Neur_chan_LBD	28..242	CDD:280998	92/217 (42%)
		Neur_chan_memb	249..525	CDD:280999	90/305 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910