Protein Alignment nAChRalpha1 and acr-6

DIOPT Version :10

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_491354.2
• Gene: acr-6 / 191479
• WormBaseID: WBGene00000045
• Length: 551
• Species: Caenorhabditis elegans
• Alignment Length: 562
• Identity: 211/562 - (37%)
• Similarity: 317/562 - (56%)
• Gaps: 74/562 - (13%)

  Fly    26 KRLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLKNQIMTTNVWVEQEWNDYKLKWNP 90
            |.|::.||:.||::..|.|..::.||::..|||.|::||:.|:|::|....:...|.||:|.|||
 Worm    21 KSLFETLLARYNKIAFPSGEFNNTLTIEFKLRLDQIVDVHEKDQVITLKGTLIHHWLDYRLSWNP 85

  Fly    91 DDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKAILHHTGKVVWKPPAIYKSFCEIDVEY 155
            |::|.:..:|.|.|.:|||||:|||||.|:..|:..|:..:...|:|.|:||.:|.:||.||:|:
 Worm    86 DEFGNITLMHFPGEMLWLPDIILYNNAHGSPWVSETTQVHVSFEGRVTWQPPVVYDAFCNIDIEW 150

  Fly   156 FPFDEQTCFMKFGSWTYDGYMVDLRHL-------KQTADSDN---IEVGIDLQDYYISVEWDIMR 210
            :|:|.|.|.:|||||||.|..::|.||       ...|..||   :|.|:||.:|..|||||::.
 Worm   151 YPYDLQICELKFGSWTYGGSQLNLIHLTTDQANESTDATGDNVWKVERGVDLSNYQESVEWDLLS 215

  Fly   211 VPAVRNEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSVLVFYLPSDSGEKISLC 275
            |..:|::|:|.||:.|.:||.:.|.:|||.||||||:|||||.::.:::.|||||.:|.:||.||
 Worm   216 VEGIRHKKWYPCCDYPSIDITYYLHIRRKKLFYTVNMIIPCVCLASMTLWVFYLPCESHQKIQLC 280

  Fly   276 ISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAVLNVNFRSPVTHRMAPW 340
            ||:|::||::||:|.:||||||:..||:.|||.|||::|.|||..|:.:.|:::|: ....|..:
 Worm   281 ISVLVALTLYFLMLIDIIPPTSIVTPLILKYLSFTMIMVALSVTCTVFIQNIHYRA-YYQPMPRF 344

  Fly   341 VQRLFIQILPKLLCIERPKKEEPEEDQPPEVLTDVYHLPPDVDKFVNYDS------KRFSGDYGI 399
            |:..||:.|.|.|.|.| |.|:.:           ||......|.||..|      |:|......
 Worm   345 VKHWFIEKLGKKLLISR-KTEQAQ-----------YHRTAQHVKQVNALSAMNILEKQFQKTLFE 397

  Fly   400 PALPASHRFDLAAAGGISAHCFAEPPL-----------PS----------SLPLPGADDDLFSPS 443
            ..:....:..:.||.......|.|.|:           ||          .|.:...||
 Worm   398 LEIATMAKKTVTAAPKTVNSIFLELPMMNRSVSVKIRKPSVKAVKNRMRRLLSIDMTDD------ 456

  Fly   444 GLNG----DISPGCCPAAAAAAAADLSPTFEKPYAREMEKTIEGSRFIAQHVKNKDKFESVEEDW 504
             :.|    :|||        ....|..|..||  .|:.||.|   .|||:.:.::.:.:..|.||
 Worm   457 -IRGKETEEISP--------ETTKDTDPDREK--LRKAEKNI---HFIAKTLTDERRAQEAEADW 507

  Fly   505 KYVAMVLDRMFLWIFAIACVVGTALIILQAPSLYDQSQPIDI 546
            ::|::|:|||.|.||:....:||.|.|..||::.|..:||.|
 Worm   508 QFVSLVIDRMLLIIFSFTITIGTILTIFSAPTMRDNREPIAI 549

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	LGIC_ECD_nAChR_proto_alpha-like	24..242	CDD:349832	96/225 (43%)
		LIC	27..530	CDD:455710	202/543 (37%)
		Cys-loop	149..163	CDD:349832	7/13 (54%)
acr-6	NP_491354.2	LGIC_ECD	21..247	CDD:475126	96/225 (43%)
		LGIC_TM_nAChR	246..>335	CDD:349866	49/88 (56%)
		TM1 helix	246..270	CDD:349866	14/23 (61%)
		Neur_chan_memb	252..524	CDD:460753	99/304 (33%)
		TM2 helix	278..299	CDD:349866	11/20 (55%)
		TM3 helix	310..332	CDD:349866	11/21 (52%)