Protein Alignment nAChRalpha1 and lgc-19

DIOPT Version :9

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_502905.2
• Gene: lgc-19 / 190895
• WormBaseID: WBGene00013655
• Length: 400
• Species: Caenorhabditis elegans
• Alignment Length: 372
• Identity: 81/372 - (21%)
• Similarity: 171/372 - (45%)
• Gaps: 69/372 - (18%)

  Fly     5 LFAAVFIAL--HFATGGLANPDAKRLYD-------DLLSNYNRLIRPV----------GNNSD-- 48
            :|:|:|:.:  .|....|..|..|...|       .:..:|:..:.||          |.:::
 Worm     5 IFSAIFMPIDSFFFDPELYVPKYKDFLDVQRNLTKHIFRDYDPTVSPVYTWVDVDLPIGYDNEAP 69

  Fly    49 -RLTVKMGLRLSQLIDVNLKNQIMTTNVWVEQEWNDYKLKWNPDDYGGVDTLHVPSEHIWLP--- 109
             |....:.|...:|::|....:.::..:.:.:.|.|.:|.||...:.....:::..:.:|.|
 Worm    70 KRYNYTIFLYYLKLVEVQEPQEKISVVMEIMEYWYDARLSWNASAWQNTTMIYMKQDKVWSPTIS 134

  Fly   110 -----DIVLYNNADGNYEVTIMTKAILHHTGKVVWKPPAIYKSF-CEIDVEYFPFDEQTCFMKFG 168
                 |||.:.:.|...       ..:.:|| .:|...::..|. ||:||..||||.|.|.::|.
 Worm   135 VFGVNDIVDFRDNDNRL-------ICIENTG-FIWDYVSVRVSANCEMDVSRFPFDTQICQIRFC 191

  Fly   169 SWTYDGYMVDLRHLKQTADSDNIEVGIDLQDYYI-----SVEWDIM----RVPA-VRNEKFYSCC 223
            ...:....||:.:          |:..::.|..|     :.||.::    ||.| |.|:...:
 Worm   192 LPIFYRVQVDILN----------EIYEEIMDERIFKTMGNSEWKLLNLTNRVEALVYNDNMGT-- 244

  Fly   224 EEPYLDI-VFNLTLRRKTLFYTVNLIIPCVGISFLSVL-VFYLPSDSGEKISLCISILLSLTVFF 286
                :|: :|.:|:||..|:|...::.|...|:|:|:: ||...:|...::::.::.::::|...
 Worm   245 ----MDLAIFEITIRRNPLYYIYMIVFPSFIINFVSIVGVFLNGADKMSRLNVGLTNIMTMTFIL 305

  Fly   287 LLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAVLNV-NFRSP 332
            .::|:.||.|. .:||||.|::..::::.:::.:..|:..: .:.||
 Worm   306 GVMADKIPRTG-NIPLLGIYIIINLVIMLIAIAIVTAITELRKWASP 351

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	Neur_chan_LBD	25..240	CDD:280998	53/254 (21%)
		LIC	27..530	CDD:273305	74/348 (21%)
		Neur_chan_memb	247..530	CDD:280999	20/88 (23%)
lgc-19	NP_502905.2	LGIC_ECD_cation	75..257	CDD:349790	45/205 (22%)
		LGIC_TM_cation	259..>346	CDD:349853	20/87 (23%)
		TM1 helix	263..284	CDD:349853	6/20 (30%)
		TM2 helix	292..313	CDD:349853	2/20 (10%)
		TM3 helix	323..346	CDD:349853	2/22 (9%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810