Protein Alignment nAChRalpha1 and acr-24

DIOPT Version :9

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_001255865.1
• Gene: acr-24 / 190686
• WormBaseID: WBGene00013534
• Length: 578
• Species: Caenorhabditis elegans
• Alignment Length: 605
• Identity: 152/605 - (25%)
• Similarity: 266/605 - (43%)
• Gaps: 143/605 - (23%)

  Fly    27 RLYDDLLS--NYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLKNQIMTTNVWVEQEWNDYKLKWN 89
            ||..||..  .|:..:|||.|:|...||...:.|.|::.:|.|.|.:..|||..|:|||..|.||
 Worm    34 RLAKDLTDPRRYDSRVRPVMNHSKPTTVSFSMSLYQILSINEKQQNVDLNVWAIQKWNDDFLGWN 98

  Fly    90 PDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYE-------VTIMTKAILHHTG-KVVWKPPAIYK 146
            |..||.::|..:|.:.|||||..|||:...|.|       |.:.|......|| :|.:..||:|:
 Worm    99 PYLYGMINTTILPFDAIWLPDTYLYNSVVMNREETERYINVVVTTNYWKGETGAEVKFMYPALYR 163

  Fly   147 SFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSD-NIE---VGIDLQDYYISVEWD 207
            :.|.:|:.:||:|:|.|.:...|||             ::.|| |.|   ..:::.::..:.||.
 Worm   164 TSCLLDIRFFPYDQQACKLTISSWT-------------SSKSDINYEPEHESVNMDNFLPNEEWV 215

  Fly   208 IMRVPAVRNEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSVLVFY----LPSDS 268
            ::.....|.|:.:.||.||::.:...|.:|||.|:|.|||:||...|:.::|..|:    ..|:.
 Worm   216 VVSFNIKRVEEKFVCCPEPWVLLEAVLVVRRKPLYYIVNLVIPTSVITLVAVTGFFTAASTSSER 280

  Fly   269 GEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAVLNVNFRSPV 333
            .||:||.|..||::::..::::|.:|.:|..|||.|.:.|..:.::.:..:.|..:|||:.:...
 Worm   281 REKLSLGIDSLLAMSILMMMVSEQMPTSSDFVPLFGIFYLSIIFIIFIGTLFTAFILNVHLQKMY 345

  Fly   334 THRMAPWVQRLFIQILPKLLCIERPKKEEPEEDQPPEVLTDVYH---------------LPPDVD 383
            ...::|.|..:|...:.:.|.:           :||.:|.::::               ..|...
 Worm   346 AKPVSPIVSYIFFGRIAQWLRM-----------RPPTMLLELWNETGVTFGKEGQKNSKTIPKNH 399

  Fly   384 KFVNYDSKRFSGDYGIPALPASHRFDLAAAGGISAHCF--------------------------- 421
            |.:...:...||.:.:.:...|.|..|||.  |||..:
 Worm   400 KMIPKVTSSSSGLHLLKSNSGSGRAPLAAP--ISARSYISMDDMKREAARRNWRRLVAKINSNKQ 462

  Fly   422 ------------------AEPPLPSSLPLPGADDDLFSPSGLNGDISPGCCPAAAAAAAADLSPT 468
                              .:...||::.:|..:              ||....:|:|.:| .|.|
 Worm   463 NGVKIVGGGERGQLRQANRKKMAPSAISVPHGE--------------PGPLMLSASAISA-FSVT 512

  Fly   469 FEKPYAREMEKTIEGSRFIAQHVKNKDKFESVEEDWKYVAMVLDRMFLWIFAIACVVGTALIILQ 533
            .:             |..:...:|.:...|     |:|:|.||||:.|.:|::.....|:::||.
 Worm   513 GD-------------STILESKLKRRYALE-----WEYLASVLDRVLLIVFSLVVFAVTSIMILD 559

  Fly   534 APSLYDQSQPIDILYSKIAK 553
            ...::      .::|..:|:
 Worm   560 LKIIH------LLVYGTVAE 573

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	Neur_chan_LBD	25..240	CDD:280998	75/226 (33%)
		LIC	27..530	CDD:273305	148/580 (26%)
		Neur_chan_memb	247..530	CDD:280999	68/346 (20%)
acr-24	NP_001255865.1	Neur_chan_LBD	34..248	CDD:280998	75/226 (33%)
		Neur_chan_memb	255..>411	CDD:280999	35/166 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010