Protein Alignment nAChRalpha1 and lgc-1

DIOPT Version :9

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_504154.5
• Gene: lgc-1 / 188099
• WormBaseID: WBGene00020236
• Length: 371
• Species: Caenorhabditis elegans
• Alignment Length: 371
• Identity: 89/371 - (23%)
• Similarity: 171/371 - (46%)
• Gaps: 81/371 - (21%)

  Fly    24 DAKRLYDDLLSNYNRLIRPVG--------NNSDRL-----TVKMGLRLSQLIDVNLKNQIMTTNV 75
            |.|||:|||..:|:..:..:.        |.:..:     .:|:.:.:.:|:||          |
 Worm    15 DQKRLWDDLFKDYDPTLSAIYTLHKSQWINQTATIHPPITELKLTMAMLKLVDV----------V 69

  Fly    76 WVEQ----------EWNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTK-- 128
            .||:          ||.|.:|||||.:|||:..::||...||||::.:   ||. :||.....
 Worm    70 EVEEKVTFLFDYLAEWTDQRLKWNPLEYGGISHIYVPQRMIWLPEVTI---ADA-HEVKFFESDD 130

  Fly   129 ----AILHHTGKVVWKPPAIYKSFCEIDVEYFPFDEQTCFMK--FGSWTYDGYMV--DLRHLKQT 185
                |.:::.|...:....:....|::||..||.|...|.:.  |.::..|.|::  |:..|.:.
 Worm   131 APRTAWINYNGTTGFYTSTVSSVICQLDVYKFPLDRHECGVSVLFHTYFADEYVIKSDMEPLPKP 195

  Fly   186 ADSDNIEVGIDLQDYYISVEWDIMRV---PAVRNEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNL 247
            ..    ::|        :.||.:..:   ..:.|..| |..:.      |...:.|...||...:
 Worm   196 LS----QLG--------NGEWKVTYIGVAEEIGNGNF-SAVQR------FVARIERNPGFYVTLV 241

  Fly   248 IIPCVGISFLSVLVFYLPSDS-GEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTM 311
            ::|...|:|||::...|..:: ||||::.::.::::|...::||:.:|.|. .:|||..|::..:
 Worm   242 MVPAFFINFLSIIALCLNIENVGEKITVGLTNIMAMTFILVILAQDLPKTK-RIPLLAIYVIVGL 305

  Fly   312 MLV--TLSVVVTIAVLNVNFR--------SPVTHRMAPWVQRLFIQ 347
            ::|  ::.||:|:.::..:.:        .||..|.:.|...|.::
 Worm   306 VIVMASIGVVLTLPLIRNHLKKRQKGKEEKPVETRFSKWFGWLTVE 351

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	Neur_chan_LBD	25..240	CDD:280998	58/250 (23%)
		LIC	27..530	CDD:273305	87/368 (24%)
		Neur_chan_memb	247..530	CDD:280999	28/112 (25%)
lgc-1	NP_504154.5	Neur_chan_LBD	84..>335	CDD:332142	68/274 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810