Protein Alignment nAChRalpha1 and lgc-16

DIOPT Version :9

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_510027.2
• Gene: lgc-16 / 187975
• WormBaseID: WBGene00011358
• Length: 401
• Species: Caenorhabditis elegans
• Alignment Length: 361
• Identity: 89/361 - (24%)
• Similarity: 166/361 - (45%)
• Gaps: 62/361 - (17%)

  Fly     5 LFAAVFIALHFATGGLANPD-------AKRLYDDLLSNYNRLI----------RPVGNNS---DR 49
            ||:...|:..:...||..|.       .:.|.:||.:||:..|          .|:|:|.   ||
 Worm     9 LFSFSDISAFYHDPGLYAPGWIDYLNLQENLTNDLFANYDPTISTVYADIADWEPLGDNPRTIDR 73

  Fly    50 LTVKMGLRLSQLIDVNLKNQIMTTNVWVEQEWNDYKLKWNPDDYGGVDTLHVPSEHIWLP----- 109
            ....:.|...:|::|....:.::..:.:.:.|.|.:|.||...|..|.|:....|.:|.|
 Worm    74 WNYTILLYYLKLVEVQEPAEKVSVVLELVERWYDPRLSWNISLYSNVSTIFARQEKVWSPTLSPF 138

  Fly   110 ---DIVLYNNADGNYEVTIMTKAILHHTGKVVWKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWT 171
               :|:.:.:.|       .....:..||.:.........:.|.:||..||||.|||.::|
 Worm   139 GVNEIIDFRDQD-------FRLISIDFTGYLNDYLSVRVSANCPMDVSRFPFDSQTCQIRF---- 192

  Fly   172 YDGYMVDLRHLKQTADSDNIEVGIDLQDYYISV----EWDIM----RVPAVRNEKFYSCCEEPYL 228
                .:.:.:::|....:.|..|| ||:..|..    ||.::    ||..::.:..|.     .:
 Worm   193 ----CLPIFNIRQVKILNEIYEGI-LQEKIIKTMGNSEWKVVSLTNRVEQLKYDDDYG-----NM 247

  Fly   229 DI-VFNLTLRRKTLFYTVNLIIPCVGISFLSVLVFYLPS-DSGEKISLCISILLSLTVFFLLLAE 291
            |: ||.:|:||..|:|...::.|...|:.:|::..:|.| |...|:::.::.::::|....::|:
 Worm   248 DLAVFEITIRRNPLYYIYMIVFPSFVINGISIVGIFLKSADKMSKLNVGLTNIMTMTFILGVMAD 312

  Fly   292 IIPPTSLTVPLLGKYLLFTM--MLVTLSVVVTIAVL 325
            .||.|. ::||||.|::..:  |::.::|||.|..|
 Worm   313 KIPRTG-SIPLLGIYIIINLLIMIIAITVVVLITEL 347

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	Neur_chan_LBD	25..240	CDD:280998	58/244 (24%)
		LIC	27..530	CDD:273305	83/332 (25%)
		Neur_chan_memb	247..530	CDD:280999	23/82 (28%)
lgc-16	NP_510027.2	LGIC_ECD_cation	77..259	CDD:349790	46/202 (23%)
		LGIC_TM	261..>317	CDD:365787	13/55 (24%)
		TM1 helix	261..284	CDD:349850	5/22 (23%)
		TM2 helix	291..315	CDD:349850	3/23 (13%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810