Protein Alignment nAChRalpha1 and lgc-13

DIOPT Version :9

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_510023.2
• Gene: lgc-13 / 187971
• WormBaseID: WBGene00011354
• Length: 399
• Species: Caenorhabditis elegans
• Alignment Length: 350
• Identity: 72/350 - (20%)
• Similarity: 152/350 - (43%)
• Gaps: 80/350 - (22%)

  Fly    31 DLLSNYNRLI----------RPVGNNSD---RLTVKMGLRLSQLIDVNLKNQIMTTNVWVEQEWN 82
            ||..||.:.:          :|:|.:.|   |....:.|...:||.||...:.::..:.:.:.|.
 Worm    41 DLFKNYEKDVSPVYAWFDTSKPLGYDPDAPQRYNYTLFLYNLKLIQVNEPEEQVSVVLELMEYWY 105

  Fly    83 DYKLKWNPDDYGGVDTLHVPSEHIWLP--------DIVLYNNADGNYEVTIMTKAILHHTGKVVW 139
            |.:|.||..||..|..:....|.||.|        :|:.:.:.|       .....:.:.|.:..
 Worm   106 DPRLSWNASDYKNVTAIFTRQEKIWSPTLTPFGVNEIIDFRDQD-------FRLVCIDNLGMIYD 163

  Fly   140 KPPAIYKSFCEIDVEYFPFDEQTCFMKFG--SWTYDGYMVDLRHLKQTADSDNIEVGI------D 196
            .......:.|.:||..||||.|||.::|.  .::|                  :||.|      .
 Worm   164 YLSVRVSANCRMDVTKFPFDSQTCQIRFSLPIFSY------------------LEVKIYTELYEG 210

  Fly   197 LQDYYI-----SVEWDIMRVP-----AVRNEKFYSCCEEPYLDI---VFNLTLRRKTLFYTVNLI 248
            :.:|.:     :.||:::.:.     ...|::|         |:   |:.:.:.|..|:|...::
 Worm   211 INNYSMFEVMGNSEWELINLTNRVDFLTYNDRF---------DVELAVYEIKIARNPLYYFYMIV 266

  Fly   249 IPCVGISFLSVL-VFYLPSDSGEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMM 312
            .|...|:.:|:: ||...:|...::::.::.::::|....::::.||.|. .|||||.|::..::
 Worm   267 FPSFVINSVSIVGVFIKGADKMSRLNVGLTNIMTMTFILGVMSDKIPRTG-NVPLLGIYIIVNLL 330

  Fly   313 LVTLSVVVTIAVLNVNFRSPVTHRM 337
            ::.:::::...:..:  |..||.::
 Worm   331 IMLVAIIIVTIITEI--RKCVTPKL 353

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	Neur_chan_LBD	25..240	CDD:280998	51/250 (20%)
		LIC	27..530	CDD:273305	72/349 (21%)
		Neur_chan_memb	247..530	CDD:280999	19/91 (21%)
lgc-13	NP_510023.2	LGIC_ECD_cation	74..257	CDD:349790	42/216 (19%)
		LGIC_TM	259..>335	CDD:365787	18/76 (24%)
		TM1 helix	259..284	CDD:349850	7/24 (29%)
		TM2 helix	292..313	CDD:349850	1/20 (5%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810