Protein Alignment nAChRalpha1 and lgc-12

DIOPT Version :10

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_498656.3
• Gene: lgc-12 / 187855
• WormBaseID: WBGene00020048
• Length: 428
• Species: Caenorhabditis elegans
• Alignment Length: 376
• Identity: 102/376 - (27%)
• Similarity: 179/376 - (47%)
• Gaps: 52/376 - (13%)

  Fly    26 KRLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLKNQIMTTNVWVEQEWNDYKLKWNP 90
            :.|...|:.:|.:..|||.|.|..|||.:..::..|::||.:|:.:...:|..|.|.|..|.|:|
 Worm    30 RELVKHLMKDYYQFTRPVKNYSSMLTVTIMPQIYNLVEVNEQNEQIKLLIWFPQSWKDDYLVWDP 94

  Fly    91 DDYGGVDTLHVPSEHIWLPDIVLYNNAD-----GNYEVTIMTKAILHHTGKVVWKPPAIYKSFCE 150
            |::.|::.:.:|...:||||..::|..:     .|:.|.:      |:.|||......:....|.
 Worm    95 DEWDGIEKITIPKSMVWLPDGYIFNTVEETDTLDNHNVRV------HYNGKVEVDFNKLIDLICP 153

  Fly   151 IDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEVGIDLQDYYISVEWDIMRVPAVR 215
            :.|..||||.|.|.::||||||..:.:....|:.:.:.:|           .:.||||:...|.:
 Worm   154 MSVLSFPFDVQLCALQFGSWTYQSHALSFNVLEASVNENN-----------KNSEWDIVAFNATK 207

  Fly   216 NEKFYSCC---EEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSVLVFYLP----SDSGEKIS 273
            ....|...   :..|.:|.:.|.:|||.|:|.|.::||...|..:|.:..:.|    .|..|.:|
 Worm   208 KVSKYMNLIGGDNVYEEIFYFLEVRRKPLYYIVVILIPTFLIVTVSNIGLFTPHGVHGDREEHVS 272

  Fly   274 LCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAVLNVNFRSPVTHRMA 338
            |.::.:|::.|...::...:|.:|..:||||.|:|....|..::|:|::.::..:.|......|.
 Worm   273 LGLTTMLTMAVILDMVTGQMPKSSEGIPLLGMYVLIEFALSIMAVLVSVLIIFAHERMLYMDAMP 337

  Fly   339 P-WVQRLF---------------------IQILPKL-LCIERPKKEEPEED 366
            | |:.|||                     :.:..:| .|||:.:|...:.|
 Worm   338 PFWIFRLFSKHKNQIPLAEMEYDDLRSSPVDLAQELRFCIEKVRKHLEDLD 388

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	LGIC_ECD_nAChR_proto_alpha-like	24..242	CDD:349832	64/223 (29%)
		LIC	27..530	CDD:455710	102/375 (27%)
		Cys-loop	149..163	CDD:349832	7/13 (54%)
lgc-12	NP_498656.3	LIC	29..>327	CDD:455710	89/313 (28%)