Protein Alignment nAChRalpha1 and acr-20

DIOPT Version :9

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_001367183.1
• Gene: acr-20 / 187632
• WormBaseID: WBGene00000059
• Length: 556
• Species: Caenorhabditis elegans
• Alignment Length: 591
• Identity: 154/591 - (26%)
• Similarity: 256/591 - (43%)
• Gaps: 110/591 - (18%)

  Fly     1 MGSVLFAAVFIALHFATGGLANPDAKRLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVN 65
            |.|...|||.: ||.......:.|...:.:.:|..||..:.|.......:.|...:.|.|:|.||
 Worm     1 MSSGRQAAVLL-LHSLVLLTVSSDQYEIANKILDKYNAGLIPSMGKKSPIEVHFSMELYQIISVN 64

  Fly    66 LKNQIMTTNVWVEQEWNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNA----DGNYEVTIM 126
            ...|.:..|.||.:.|.|..|.|:|:.:|.|..:.:|...|||||..|||:.    |.|
 Worm    65 EPQQFLMLNAWVVERWTDRLLGWDPEKFGNVTEIMLPHHFIWLPDTTLYNSLVMKDDEN------ 123

  Fly   127 TKAILHHTGKVVWKP-----------PAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLR 180
             :.:||  .||....           |.|||..|.:::.:||||.|:|.:.|||||:|...:|..
 Worm   124 -RRLLH--AKVTTLGEGNGAFIELLYPTIYKLSCLLNLRFFPFDVQSCRLLFGSWTFDNTKIDYF 185

  Fly   181 HLKQTADSDNIEVGIDLQDYYISVEWDIMRVPAVRNEKFYSCCEEPYLDIVFNLTLRRKTLFYTV 245
            ...::.       .|...:...:..|:::....:|:|..|.||...|..:.|.||::||.|:|.:
 Worm   186 AFNESQ-------AIGTTNCIENEGWNVLSTSVIRHENKYDCCPNNYTLLEFRLTIQRKPLYYII 243

  Fly   246 NLIIPCVGISFLSVLVFYLPSDSG----EKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKY 306
            |||||...|:|:|::.|:..|...    |||:|.|:.|||:::...::::.:|.||..:||:|.:
 Worm   244 NLIIPTSIITFISIIGFFSTSSINEPREEKITLGITTLLSMSILIFMVSDKMPSTSSFIPLIGLF 308

  Fly   307 LLFTMMLVTLSVVVTIAVLNV----NFRSPVTH---RMAPWVQRLFIQILP---KLLCIERPKKE 361
            ....::|::.|.:.:..|:.|    |..:|.:.   .:|..|.|.....:|   |....::.::|
 Worm   309 YTSMILLISFSTICSSVVIYVQKQGNLGNPPSKNFMNIARAVNRFIRMEMPLIMKQAYAQKAREE 373

  Fly   362 EPEEDQ---PPEVLTDVYHLP------PDV---------------DKFVNYDSKRFSGDYGIPAL 402
            :....|   ...:.|.||.|.      .||               :|.::...||.:.:..:..:
 Worm   374 KLRRQQMGRKQSLWTRVYKLAREQALRKDVQTSQNSSKFNEVLTPEKLIDNGGKRCTINKDVTCI 438

  Fly   403 PASHRFDLAAAGGISAHCFAEPPLPSSLPLPGADDDLFSPSGLNGDISPGCCPAAAAAA---AAD 464
            ..|         ||.|         ..:|...::||....|.|..:.:|  .||.....   .|.
 Worm   439 SDS---------GIVA---------MGVPTLASEDDDQDVSLLELETTP--TPAMQRPTRLHKAS 483

  Fly   465 LSPTFEKPYAREMEKTI--EGSRFIAQHVKNKDKFESVEEDWKYVAMVLDRMFLWIFAIACV--- 524
            ...:|:....|::|..:  ..:|.:|:          :|.||  :|.:|:|:||..|....|
 Worm   484 TCGSFDSMMFRQIEVPVSPRTARNLAE----------IEYDW--LAALLERIFLITFLFIFVLTS 536

  Fly   525 VGTALI 530
            :|..||
 Worm   537 IGINLI 542

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	Neur_chan_LBD	25..240	CDD:280998	66/229 (29%)
		LIC	27..530	CDD:273305	144/563 (26%)
		Neur_chan_memb	247..530	CDD:280999	74/328 (23%)
acr-20	NP_001367183.1	Neur_chan_LBD	24..238	CDD:397192	66/229 (29%)
		LGIC_TM_cation	239..>329	CDD:349853	29/89 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010