DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRalpha1 and acr-21

DIOPT Version :9

Sequence 1:NP_001262916.1 Gene:nAChRalpha1 / 42918 FlyBaseID:FBgn0000036 Length:597 Species:Drosophila melanogaster
Sequence 2:NP_001355512.1 Gene:acr-21 / 185004 WormBaseID:WBGene00000060 Length:635 Species:Caenorhabditis elegans


Alignment Length:662 Identity:205/662 - (30%)
Similarity:312/662 - (47%) Gaps:163/662 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 AVFIALHFATGG-----LANPDAKRLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLK 67
            ::|:..:.|.||     .|:.:..|||.|||.:||..:||..::.:.:.|.....|:|:|||:.:
 Worm     9 SLFLFFNGAHGGNELSSRADQNVMRLYRDLLYDYNNEVRPSVHSKEPINVTFVFSLTQIIDVDER 73

  Fly    68 NQIMTTNVWVEQEWNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIM-TKAIL 131
            |||:|||.|:...|.||||.|:|..|..|..:|:||:.||.|||:||||||..|..::| |..|:
 Worm    74 NQILTTNSWIRLHWVDYKLVWDPRLYQNVTRIHIPSDKIWKPDIILYNNADAQYMKSVMSTDVIV 138

  Fly   132 HHTGKVVWKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEVGID 196
            .:.|.:.|...||:.|.|.:||:::|||.|||.:|:.||.|||..:||. ||.       |.| |
 Worm   139 DYLGNIHWPLSAIFTSSCPLDVKHYPFDRQTCILKYASWAYDGTKIDLL-LKS-------EQG-D 194

  Fly   197 LQDYYISVEWDIMRVPAVRNEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSVLV 261
            |.:|..:.||.::.:.|.:|:..||||.|||..|..::|:.|:.:||..|||:|||.||.::::.
 Worm   195 LTNYITNTEWSLIGIRAEKNQVIYSCCPEPYPFIDVHVTIERRAMFYVFNLILPCVLISLIALMG 259

  Fly   262 FYLPSDSGEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAVLN 326
            ||:|:|||||::|.|:.|||.|||.:::||.:|||:..:||:|.|...|:|||.|...:|:..:|
 Worm   260 FYMPTDSGEKVTLGITSLLSTTVFLMMVAEGMPPTAEALPLIGIYFGVTIMLVALGTAMTVFTVN 324

  Fly   327 VNFRSPVTHRMAPWVQRLFIQILPKLLCI------------------ERP--------------- 358
            ::......:.:.|::|....:.|.|:|.:                  |.|               
 Worm   325 IHHTGVHGYPVPPFLQIFAFRYLSKILFVRIEPYHSIAHHVRYMYQKEHPTECTLSASVHYKRLH 389

  Fly   359 -------KKEEP---EEDQPP-EVLTDVYHLPPDVDKFV-----------NYDSKR--------- 392
                   ||||.   :.|... .|::...|..|| |:.:           .:||::         
 Worm   390 DFDANVAKKEEQYGLQRDMSNLSVISANVHCNPD-DRLLLGSQSSQKNLNKFDSEKNLRSSLSIR 453

  Fly   393 ---------------------------------FS--GDYGIP---------------ALPASHR 407
                                             ||  ..:|.|               ..|.|..
 Worm   454 SGSPTAKKKGHVRVSNIARSTRIMETDVSHLVSFSSLNSHGTPIDSPIYGRKLGRTQSQTPTSSY 518

  Fly   408 FDLAAAGGISAHCFAEPPLPSSLPLPG----AD-DDLFSPSGLNGDISPGCCPAAAAAAAADLSP 467
            .:....|||::     .|||..|..|.    .| ||:|..   |.:..|             :..
 Worm   519 RNSNGNGGITS-----DPLPQQLSNPPKISLTDVDDVFEN---NENQQP-------------MVD 562

  Fly   468 TFEKPYAREMEKT---IEGSRFIAQHVKNKDKFESVEEDWKYVAMVLDRMFLWIFAIACVVGTAL 529
            .|||.:.|.|...   ||.:.   ..|..|||.:::..:|:.|||||||..|.:|.|...:.| .
 Worm   563 EFEKEFLRVMSMVHGIIERNE---MRVAEKDKRDAIALEWQQVAMVLDRFLLVVFLIGTSMST-F 623

  Fly   530 IILQAPSLYDQS 541
            :||...:|::.:
 Worm   624 VILNQRNLFEST 635

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha1NP_001262916.1 Neur_chan_LBD 25..240 CDD:280998 93/215 (43%)
LIC 27..530 CDD:273305 197/625 (32%)
Neur_chan_memb 247..530 CDD:280999 101/404 (25%)
acr-21NP_001355512.1 LGIC_ECD_nAChR 56..237 CDD:349798 82/189 (43%)
Cys-loop 156..170 CDD:349798 7/13 (54%)
LGIC_TM_cation 239..>327 CDD:349853 42/87 (48%)
TM1 helix 239..263 CDD:349853 12/23 (52%)
TM2 helix 271..292 CDD:349853 10/20 (50%)
TM3 helix 303..325 CDD:349853 7/21 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3645
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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