Protein Alignment nAChRalpha1 and lgc-21

DIOPT Version :10

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_510341.2
• Gene: lgc-21 / 181516
• WormBaseID: WBGene00007903
• Length: 462
• Species: Caenorhabditis elegans
• Alignment Length: 348
• Identity: 78/348 - (22%)
• Similarity: 138/348 - (39%)
• Gaps: 66/348 - (18%)

  Fly    20 LANPDAKRLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLKNQIMTTNVWVEQEWNDY 84
            ||...||:|....:.:....|.|...:...:|:.......|..::|...:.::.:.::|..|:|.
 Worm    83 LAGESAKKLAKLNIPHAIASIPPNYLSQQPVTINFAQFTLQHFELNEHLKDISIHGYLELSWHDD 147

  Fly    85 KLKWNPDDYGG----VDTLHVPSEHIWLPDIVLYN------NADGNYEVTIMTKAILHHTGKVVW 139
            :|.||.|.:..    |.:.|    |||:|.:...|      |.|. :|:   .|....:.|.|..
 Worm   148 RLMWNQDTWKKNKLVVHSFH----HIWVPLLGSQNPENHLKNGDA-FEI---RKVETTNQGNVSA 204

  Fly   140 KPPAIYKSFC-EIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEVGID---LQDY 200
            |.....::|| :.|.|.:|.|...|...|..      ..|...::.|  |..:.:..|   .:||
 Worm   205 KVAFSLRTFCDDTDFENYPNDVYKCCFSFEP------QQDREVIQFT--SSGLPIFTDPKNFRDY 261

  Fly   201 YISVEWDIM-RVPAVRNEKFYSCCEEP--YLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSVLVF 262
                .|.:. .||    |.|    ::|  ...:.|.|.|:|......:.|.||.    |::..:|
 Worm   262 ----GWGVSGTVP----ESF----DDPSEIAQLGFCLNLKRAHSSLKIELAIPL----FITTALF 310

  Fly   263 YLPSDSGE-KISLCISI------LLSLTVFFLLLAEIIPPTSLT---VPLLGKYLLFTMMLVTLS 317
            .||...|. ||.:.:.:      .::|.:|...:|..:..|:.|   :..|...|:|.::.:|.|
 Worm   311 LLPPLFGSVKIQIYLKMFVMGLQFMTLLIFSTRIAPFLSSTASTPKPMRFLEIALVFNLISITTS 375

  Fly   318 VVVTIAVLNVNFRSPVTHRMAPW 340
            :::...:       .|...:.||
 Worm   376 IIIFCCM-------QVKRTLPPW 391

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	LGIC_ECD_nAChR_proto_alpha-like	24..242	CDD:349832	53/234 (23%)
		LIC	27..530	CDD:455710	74/341 (22%)
		Cys-loop	149..163	CDD:349832	5/14 (36%)
lgc-21	NP_510341.2	LGIC_ECD	113..290	CDD:475126	47/204 (23%)