Protein Alignment nAChRalpha1 and acr-12

DIOPT Version :10

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_510262.1
• Gene: acr-12 / 181475
• WormBaseID: WBGene00000051
• Length: 573
• Species: Caenorhabditis elegans
• Alignment Length: 630
• Identity: 250/630 - (39%)
• Similarity: 352/630 - (55%)
• Gaps: 133/630 - (21%)

  Fly    11 IALHFATGGLANPDAKR--------LYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLK 67
            :.|..|.||......||        ||:|||.:||::.|||.|:||.|||.:|..|.::|||:.|
 Worm    16 LILLVAVGGTNAFKIKRTAKDLESQLYEDLLFDYNKVPRPVKNSSDILTVDVGASLIRIIDVDEK 80

  Fly    68 NQIMTTNVWVEQEWNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKAILH 132
            ||::|||:|:|.:|||.||.|.|:.|||:.|||:||:.||.||:||||||.|:.::||:|.|::.
 Worm    81 NQVLTTNLWLEMKWNDAKLTWTPEKYGGLKTLHIPSDFIWTPDLVLYNNAAGDPDITILTDALVT 145

  Fly   133 HTGKVVWKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQ------TADSDNI 191
            ..|.|.|:|||||||||.|||.:||:|.|.|.||||:|||.|..|||:.|.|      |.|.:::
 Worm   146 FEGNVYWQPPAIYKSFCPIDVTWFPYDSQKCEMKFGTWTYTGRYVDLKQLPQEEVVTITKDDNDV 210

  Fly   192 EV---GIDLQDYYISVEWDIMRVPAVRNEKFY-SCC-EEPYLDIVFNLTLRRKTLFYTVNLIIPC 251
            |.   |:||..:|.|.|||::.:.:.|:...| ||| .|.|:||.:...|||||||:|.|||:||
 Worm   211 EFMQQGMDLSFFYRSAEWDLLSLTSERHSVLYASCCGPEKYVDITYYFGLRRKTLFFTCNLILPC 275

  Fly   252 VGISFLSVLVFYLPSDSGEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTL 316
            ..||.|:..||||   |..||:..||||::||||||:|.:::|||||.:|:.|:||:.||:||.|
 Worm   276 FLISILTTFVFYL---SDHKITFSISILVTLTVFFLVLIDLMPPTSLVIPMFGRYLITTMILVAL 337

  Fly   317 SVVVTIAVLNVNFRSPVTHRMAPWVQRLFIQILPKLLCIERPKKEEPEEDQPPEVLTDVYHLPPD 381
            |.||::..:|..|||...|:|:||::.:|::.|||:|.:.||:|.|..: |||
 Worm   338 STVVSVITVNFRFRSGSAHKMSPWIRAVFLKFLPKILLMSRPEKGEVTK-QPP------------ 389

  Fly   382 VDKFVNYDSKRFSGDYGIPALPASHRFDLAAAGGISAHCFAEPPLPSSLPLPGADDDLFSPSGLN 446
               .||..| ....:|...|..|:...:.|                     .|.::||.|..|.
 Worm   390 ---LVNAAS-LVGSNYATAAKAANEYRNKA---------------------KGKNNDLMSLRGK- 428

  Fly   447 GDISPGCCPAAAAAAAADLSPTFE--------------KPY----------------AREMEKTI 481
                    |::.|.    |:.||:              |||                .|:..|::
 Worm   429 --------PSSQAV----LNNTFDMRMRNNDSTVENRLKPYLCAQNNNAPTVAFRKTKRQKSKSV 481

  Fly   482 EG---------SRFIAQHVKNKDKFESVEEDWKYVAMVLDRMFLWIFAIACVVGTALIILQAPSL 537
            :.         .||||:|.::.:....:.:||.:|||||||:||.||:: ..|||..|||::|||
 Worm   482 DDVVFMNLLNQVRFIAEHFRHNELEGEISDDWTFVAMVLDRLFLIIFSV-LNVGTVFIILESPSL 545

  Fly   538 YDQSQPIDILYSKIAKKKFELLKMGSENTLXRPLGFAAGW--WNL 580
            ||.|:|::|....                  :|||.|..:  |||
 Worm   546 YDYSKPMNITVPN------------------KPLGQANFYSSWNL 572

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	LGIC_ECD_nAChR_proto_alpha-like	24..242	CDD:349832	119/236 (50%)
		LIC	27..530	CDD:455710	227/560 (41%)
		Cys-loop	149..163	CDD:349832	8/13 (62%)
acr-12	NP_510262.1	LIC	14..539	CDD:455710	232/577 (40%)
		LGIC_ECD	40..266	CDD:475126	117/225 (52%)