Protein Alignment nAChRalpha1 and lgc-4

DIOPT Version :9

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_509556.4
• Gene: lgc-4 / 181155
• WormBaseID: WBGene00017580
• Length: 635
• Species: Caenorhabditis elegans
• Alignment Length: 534
• Identity: 155/534 - (29%)
• Similarity: 270/534 - (50%)
• Gaps: 48/534 - (8%)

  Fly    28 LYDDLLSN--YNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLKNQIMTTNVWVEQEWNDYKLKWNP 90
            ||..||.:  |.:.:||..::|....|..|..|:|:::::.:||.:||..|:...|.|.:|.||.
 Worm   114 LYRSLLDHTVYEKDVRPCIHHSQPTNVTFGFLLNQIVEMDERNQALTTRSWLNINWMDPRLSWNE 178

  Fly    91 DDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIM-TKAILHHTGKVVWKPPAIYKSFCEIDVE 154
            ..:..:..:::|...||.|||:|.|||...|..::: |..::...|.|.|...|:::|.|.|.|.
 Worm   179 SLWSEIKAIYIPHARIWKPDIILVNNAIREYYASLVSTDVMVTSDGNVTWLFSALFRSSCPIRVR 243

  Fly   155 YFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEVGIDLQDYYISVEWDIMRVPAVRN-EK 218
            |:|||:|.|.:||.||::|...::|        ..|.:.| ||..|..:.|:|::.:.|||. ..
 Worm   244 YYPFDDQQCDLKFASWSHDITEINL--------GLNTDKG-DLSSYMNNSEFDLVDMTAVREVVT 299

  Fly   219 FYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSVLVFYLPSDSGEKISLCISILLSLT 283
            |.|.....:..||..:.:.|:.|||..|.|:|||.||.::||.|.:|.::||||::.|:.|||:.
 Worm   300 FPSDTNSDWPIIVIRIHMHRRPLFYVFNHIVPCVLISSMAVLGFLMPPETGEKINMIITTLLSMG 364

  Fly   284 VFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAVLNVNFRSPVTH-RMAP-WVQRLFI 346
            |:...:.|.|||||..|||:|.|.:.::::|.|:..|.:..||::....... |..| |:|:..:
 Worm   365 VYLQSITESIPPTSEGVPLIGMYYVSSLLMVCLATCVNVITLNMHRNGAANQGRHVPAWMQKWIL 429

  Fly   347 QIL----------PKLLCIERPKKEEPEEDQPPEVLTDVYHLPPDVDKFVNYDSKRFSGDYGIPA 401
            ..|          |..:.:.:..:.:....:...:|.|:..:....:  |...||..:.:.....
 Worm   430 GYLATFMRMSIREPDSIALLKASQSKKSTIRRSSILRDLKRVKNMSN--VRAKSKEQNANRECEC 492

  Fly   402 L-PASHRFDLAAAGGISAHCFAEPPLPSSLPLPGAD--DDLFSPSGLNGD-ISPGCCPAAAAAAA 462
            : |..|.:    |..|.: |.|    ..:.|:.|:.  :|..|.|...|. :|.|..|..:|::.
 Worm   493 MDPLVHIY----AESIMS-CLA----ADTKPMNGSTIREDFASESTFLGRVVSDGIMPRISASSN 548

  Fly   463 ADLSPTFEKPYAREMEKTIEGSRFIAQH-VKNK--DKFESVEEDWKYVAMVLDRMFLWIFAIACV 524
            :.|: .||..:.|.:::..   |.:.|| ::.:  |:...::..|:.:|.|:||:.|.:|..|.:
 Worm   549 SVLT-EFETRFRRILKRVY---RSLQQHEIREEILDERSRIQWQWQQLASVVDRLLLCLFCTATL 609

  Fly   525 VGTALIILQAPSLY 538
            . |.:.:|..|..|
 Worm   610 F-TIICLLIVPVAY 622

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	Neur_chan_LBD	25..240	CDD:280998	69/215 (32%)
		LIC	27..530	CDD:273305	152/524 (29%)
		Neur_chan_memb	247..530	CDD:280999	79/301 (26%)
lgc-4	NP_509556.4	Neur_chan_LBD	111..321	CDD:280998	69/215 (32%)
		Neur_chan_memb	329..>457	CDD:280999	41/127 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810