Protein Alignment nAChRalpha1 and lgc-26

DIOPT Version :9

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_503167.1
• Gene: lgc-26 / 178554
• WormBaseID: WBGene00021981
• Length: 486
• Species: Caenorhabditis elegans
• Alignment Length: 572
• Identity: 122/572 - (21%)
• Similarity: 212/572 - (37%)
• Gaps: 149/572 - (26%)

  Fly     9 VFIALHFATGGLANPDAKRLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLKNQIMTT 73
            |.|..||......:.|.::|...||..||..:|||...|....|.:.|.::.:..|:...|....
 Worm    11 VLINFHFGNAASQSTDERKLEAQLLKGYNSKVRPVKVESTVTQVAVYLNIAHVEKVDEHEQTALV 75

  Fly    74 NVWVEQEWNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMT--KAILHHTGK 136
            :..:...|.|..|||. .....:.||.:.|..:|.|.:.|||:|.||.....:|  .||:::|||
 Worm    76 HGHLMASWTDEYLKWE-RKATNISTLSIASSKLWQPALQLYNSARGNSWSLYLTGLPAIVYNTGK 139

  Fly   137 VVWKPPAIYKSF---CEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTA------------ 186
             ||.....  ||   |:.|...:|:|:|:|.:....|.|....|:|......|
 Worm   140 -VWSRGTF--SFFVTCQFDFTNWPYDQQSCPIVITDWVYGLGQVNLSDPATAAGYGKPTIRLSYD 201

  Fly   187 ---DSDNIEVGIDLQDYYISVEWDIMRVPAVRNEKFY---SCCE-EP------YLDIV-FNLTLR 237
               :::...||          .|::  :.:.:...::   .|.: ||      |..:: |.:||:
 Worm   202 PIDETNKRHVG----------GWEV--IDSWKKHCYWGPKGCLDAEPDGNPDWYWSLLEFGITLK 254

  Fly   238 RKTLFYTVNLIIPCVGISFLSVLVFYLPSDSGEKISLCISILLSLTVFFLLLAEIIPPTSLTVPL 302
            |...::::.:::|.|..|.:.:|.|::.:.......:.::|.|..|....:|:.:.|.:..|..:
 Worm   255 RHLPYFSLTIVMPMVSTSLMILLGFWIENFDFNVFLITLNIALQATYGSNILSRMPPGSGRTPKI 319

  Fly   303 LGKYLL------FTMMLVTLSVVVTIAV---LNVNFRSPVTHRMAPWVQRLFIQILPKLLCIER- 357
            :..|.:      |.::|:.:|..:.:.:   ...:|...:|.             :||...:.|
 Worm   320 VHLYSIGLLISAFQVVLIVMSNFLRVRLPSHYEFDFGYDITE-------------IPKKFGLTRF 371

  Fly   358 ----PKKEEPEEDQPPEVLTDVYHLPPDVDKFVNYDSKRFSGDYGIPALPASHRFDLAAAGGISA 418
                ....:|:|...|..||....:           .|..|...||
 Worm   372 FTTKGLSFDPQELLNPAQLTSEAEI-----------QKEASTSIGI------------------- 406

  Fly   419 HCFAEPPLPSSLPLPGADDDLFSPSGLNGDISPGCCPAAAAAAAADLS--------PTFEKPYAR 475
                ..||..|    |:|.||......|.:              ||||        |..||. .:
 Worm   407 ----SNPLAES----GSDTDLLINLPKNSE--------------ADLSERSETLGMPDSEKT-QK 448

  Fly   476 EMEKTIEGSRFIAQHVKNKDKFESVEEDWKYVAMVLDRMFLWIFAIACVVGT 527
            |.:|.:........|:|....|        :|      :|:::|||..|:.|
 Worm   449 ESQKKMRKLEIQLLHIKRFAFF--------FV------IFVYLFAILLVLAT 486

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	Neur_chan_LBD	25..240	CDD:280998	61/245 (25%)
		LIC	27..530	CDD:273305	117/554 (21%)
		Neur_chan_memb	247..530	CDD:280999	56/303 (18%)
lgc-26	NP_503167.1	LGIC_ECD_cation	52..256	CDD:349790	51/219 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910