Protein Alignment nAChRalpha1 and lev-1

DIOPT Version :10

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_001255705.1
• Gene: lev-1 / 178269
• WormBaseID: WBGene00002974
• Length: 507
• Species: Caenorhabditis elegans
• Alignment Length: 573
• Identity: 211/573 - (36%)
• Similarity: 322/573 - (56%)
• Gaps: 96/573 - (16%)

  Fly     1 MGSVLFAAVFIALHFATGGLANPDAKRLYDDLLSNYNRLIRPVGNNSD-RLTVKMGLRLSQLIDV 64
            :|.::|.||.:..|.....:...|  ||..||...||.|::||.|.|: .:.||:|::|..||:|
 Worm    16 LGFLVFLAVSLRNHSTCEDIDAED--RLMVDLFRGYNSLVQPVRNRSELPMIVKIGMQLVLLINV 78

  Fly    65 NLKNQIMTTNVWVEQEWNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKA 129
            :.|.|:|.||||:..:|:|::|||:|.||..:..:.|..|.:|||||||:|||||||||:.|...
 Worm    79 DEKEQVMHTNVWLTMKWDDFQLKWDPRDYANITQIRVAPEKVWLPDIVLFNNADGNYEVSFMCNV 143

  Fly   130 ILHHTGKVVWKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEVG 194
            ::..||.|:|.|||||||.|.||||:||||:|.|.:.||||||:...:.|..|  |:|.
 Worm   144 LILSTGTVLWVPPAIYKSSCIIDVEFFPFDDQLCSLTFGSWTYNRDEIKLDFL--TSDR------ 200

  Fly   195 IDLQDYYISVEWDIMRVPAV----RNEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGIS 255
            :|..:|..|..||:|..|||    |:.            |.|.:.:|||||||||.||:|.|.::
 Worm   201 VDFSEYSTSSIWDMMDGPAVLTSDRSR------------IEFQIRIRRKTLFYTVVLILPTVLMA 253

  Fly   256 FLSVLVFYLPSDSGEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVV 320
            ||:|.|||||:.||||:.|.:::|||:.||.||:::|:||||.::||:.||||.|.:|..::::|
 Worm   254 FLNVTVFYLPTASGEKMGLTMNVLLSIVVFLLLVSKILPPTSSSIPLVAKYLLLTFVLNIITIMV 318

  Fly   321 TIAVLNVNFRSPVTHRMAPWVQRLFIQILPKLLCIERPKKEEPEEDQPPEVLTDVYHLPPDVDKF 385
            |..:.|:.||||:|||:.|||:::|:.|||.|:|::||.::...:.....:|    ...|.|:
 Worm   319 TTIICNIYFRSPITHRLPPWVRKVFLDILPLLMCMQRPHRKNVIQRSHRRLL----ETGPSVE-- 377

  Fly   386 VNYDSKRFSGDYGIPALPASHRFDLAAAGGISAHCFAEPPLPSSLPLPGADDDLFSPSGLNGDIS 450
               ::...||::. |....:|..|......|.:                  |:      |:.::|
 Worm   378 ---ENPMRSGEHH-PLCRHTHNQDSCRRVRIQS------------------DE------LDDELS 414

  Fly   451 PGCCPAAAAAAAADLSPTFEKPYAREMEKTIEGSRFIAQHVKNKDKFESVEEDWKYVAMVLDRMF 515
            |                        |.::.|:...||.::.::::..:...:|||::|.|:||..
 Worm   415 P------------------------EAQRAIDAIEFITENRRDEEITKQFRDDWKFIASVVDRFL 455

  Fly   516 LWIFAIACVVGTALIILQAPSL---YDQSQPIDILYSKIAKKKFELLKMGSEN 565
            |:.|..|.|.||..||..|||:   :|::       :.:.|.| :|..||..|
 Worm   456 LYGFFGATVGGTIGIIFTAPSVFETFDEN-------ATLVKLK-QLYDMGLAN 500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	LGIC_ECD_nAChR_proto_alpha-like	24..242	CDD:349832	101/222 (45%)
		LIC	27..530	CDD:455710	193/507 (38%)
		Cys-loop	149..163	CDD:349832	10/13 (77%)
lev-1	NP_001255705.1	LIC	15..474	CDD:455710	201/537 (37%)
		LGIC_ECD_nAChR_proto_beta-like	37..238	CDD:349833	99/222 (45%)
		Cys-loop	163..177	CDD:349833	10/13 (77%)