Protein Alignment nAChRalpha1 and cup-4

DIOPT Version :9

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_498710.2
• Gene: cup-4 / 176104
• WormBaseID: WBGene00000845
• Length: 433
• Species: Caenorhabditis elegans
• Alignment Length: 383
• Identity: 78/383 - (20%)
• Similarity: 139/383 - (36%)
• Gaps: 82/383 - (21%)

  Fly    28 LYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLKNQIMTTNVWVEQEWNDYKLKWNPDD 92
            |...:...||...||:.|.|....|.:...:.. :.:|.:.|.||.:..:...|.|..|.|:|.|
 Worm    51 LEQKIFRGYNPKNRPMKNASFPTIVDVHWHIIH-VSINQREQTMTVHGHIYMRWFDEFLVWDPKD 114

  Fly    93 YGGVDTLHVPSEHIWLPDIVLYNNADG---NYEVTIMTKAILHHTG----KVVWKPPAIYKSFCE 150
            :..:....|....:|.|.|.:.|:|.|   .::.:.....|:...|    ||...|....|..|.
 Worm   115 FNNIQYARVKKWQVWQPKIKVSNSASGLGSAFDFSTSAHVIIQMMGKDRAKVEMYPTFSIKVGCA 179

  Fly   151 IDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEVGIDLQDYY-----ISVEWDIMR 210
            .|...:|:|...|            .::|......||       :.||:.|     :|..|:..:
 Worm   180 FDFTDYPYDLNKC------------AINLFSTSTMAD-------VQLQNLYAIPPTLSFGWEEQK 225

  Fly   211 VPAVRNE-KFYSCCEEPYLDIVFNLT-----------------------LRRKTLFYTVNLIIPC 251
            :..:.:: |..:...........|:|                       :|...||... ::.||
 Worm   226 MKRIISDFKIQNVSSSALYYTNGNITSSAPITGFDLGSTWSMLAVTVSFVRHSPLFEAA-VVTPC 289

  Fly   252 VGISFLSVLVFYLPSDSGEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTL 316
            :.::.|..:.|::.|.|...:.:.:...:.| :|...|.|.:|.:...:|...|.:...|....|
 Worm   290 IVVASLISMTFFIDSLSSTFLLMMLHFYVQL-IFLHDLVEKLPLSVSEIPFCIKLIGILMYTNGL 353

  Fly   317 SVVVTIAVL-NVNFRSPVTHRMAPWVQRLFIQILPKLLCIE-----------RPKKEE 362
            ::|:..::| ...::.||.            |.|.|:..||           :.||||
 Worm   354 TLVLHSSLLCGSYYKCPVP------------QQLNKIFVIEEYIPNTFKEKVQIKKEE 399

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	Neur_chan_LBD	25..240	CDD:280998	48/247 (19%)
		LIC	27..530	CDD:273305	78/383 (20%)
		Neur_chan_memb	247..530	CDD:280999	28/128 (22%)
cup-4	NP_498710.2	Neur_chan_LBD	48..>222	CDD:280998	43/190 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910