Protein Alignment nAChRalpha1 and lgc-20

DIOPT Version :9

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_496423.1
• Gene: lgc-20 / 174733
• WormBaseID: WBGene00007191
• Length: 454
• Species: Caenorhabditis elegans
• Alignment Length: 373
• Identity: 79/373 - (21%)
• Similarity: 149/373 - (39%)
• Gaps: 87/373 - (23%)

  Fly    46 NSDRLTVKMGLRLSQLIDVNLKNQIMTTNVW--VEQEWNDYKLKWN-PDDYGGVDTLHV-PSEHI 106
            |||.:|:.:...|.:.::: :|......||:  :...|.|.::||: ..::...:.|:: .|..|
 Worm    64 NSDEMTITIENVLVKYVEL-VKGSSYQFNVFGDIYLNWKDERMKWDKKGEFENYEHLYIFNSSAI 127

  Fly   107 WLPDIV---LYNNADGNYEVTIMTKAILHHTGKVVWKPPAIYKSFCEIDVEYFPFDEQTCFMKFG 168
            |.|.::   |.:....:|.|..:.   ::..|.:..:....|.:.|.:|...||.::.:|.:.|
 Worm   128 WTPHVIDHTLCSEGGCSYSVDDVD---IYDDGTIYARIQFKYLASCTVDYRKFPEEDDSCCIFF- 188

  Fly   169 SWTYDGYMVDLRHLKQTADSDNIE-VGIDLQDYYISVEWDIMRVPAVRNEKFYSCCEEPYLDI-- 230
                            ||...|:| ..:.|:    ..|.:.|..| |..:|.|. .|:...||
 Worm   189 ----------------TAFEPNVEQTTLVLE----GKEKEKMNRP-VYAQKIYE-KEKQLSDIVQ 231

  Fly   231 ------------------------VFNLTLRRKTLFYTVN--LIIPCVGISFLSVLVFYLPSDSG 269
                                    |..:.:|.:....||.  |:.| |.::...:|...|..|..
 Worm   232 EHSPWVVVEKTMSTSNLGGLKSLQVMQVCVRAEKQMSTVRVALLFP-VTLATYVMLASPLFGDLR 295

  Fly   270 EKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLG---KYLLFTMMLVT---LSVVVTIAVL--- 325
            .:|.:.:..|...|:.||.|..|.|...    .||   :..:|..::.|   :|::||:.|:
 Worm   296 TQIYVKLFSLHIQTLCFLYLCTITPLNG----FLGVRPRIYIFYELIFTISFMSILVTLVVMALS 356

  Fly   326 NVNFRSPVTHRMAPWVQRLFIQILPKLLCIERPKKEEP-----EEDQP 368
            .|....|.:||:.     |..:::.:::|...|::.:.     |||.|
 Worm   357 RVKRNVPPSHRLF-----LSAKLINRVVCCIEPERSDAYHRYVEEDTP 399

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	Neur_chan_LBD	25..240	CDD:280998	44/227 (19%)
		LIC	27..530	CDD:273305	79/373 (21%)
		Neur_chan_memb	247..530	CDD:280999	33/136 (24%)
lgc-20	NP_496423.1	LGIC_ECD	68..>206	CDD:355788	30/162 (19%)
		Cys-loop	170..184	CDD:349787	4/13 (31%)
		DUF2070	274..>365	CDD:391572	24/95 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810