Protein Alignment nAChRalpha1 and acr-7

DIOPT Version :9

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_495647.1
• Gene: acr-7 / 174262
• WormBaseID: WBGene00000046
• Length: 538
• Species: Caenorhabditis elegans
• Alignment Length: 593
• Identity: 188/593 - (31%)
• Similarity: 282/593 - (47%)
• Gaps: 113/593 - (19%)

  Fly     4 VLFAAVFIALHFATGGLANPDAKR---LYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVN 65
            ||..|:|..:.|  .|.....:|:   ||.|||:||:.|:|||.|....|||.|.:.:.|::.|:
 Worm     9 VLPVALFFLIVF--NGFTVEGSKKEAQLYRDLLTNYSYLVRPVRNPKKALTVTMKVFIQQVLLVD 71

  Fly    66 LKNQIMTTNVWVEQEWNDYKLKWNPDDYGGVDTLHVPSE-HIWLPDIVLYN----NADGNYEVTI 125
            .|:|::..|.|::..|.|::|:|||.||..:.::....| .||.|||:|||    :...::::|.
 Worm    72 AKHQMIEVNAWLKYIWTDFRLRWNPLDYENITSVRFQGEDQIWQPDILLYNRYIEDEQESFDITY 136

  Fly   126 MTKAILHHTGKVVWKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDN 190
            .|.|:.:..|.:.|.||.|:|..|::|:..||||||.||||||||||.|:.:|||       .|.
 Worm   137 KTNAVAYSDGVINWIPPGIFKLSCKMDITLFPFDEQICFMKFGSWTYHGFALDLR-------LDV 194

  Fly   191 I---EVGIDLQDYYISVEWDIMRVPAVRNEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCV 252
            :   |...||..|..:.||.::..||.|.||||.||:|||..:.|.|.|||:|.:|..|:::|.:
 Worm   195 VKGQEPSADLSTYITNGEWHLLSAPARREEKFYKCCKEPYPTVKFYLHLRRRTFYYVFNVVLPTL 259

  Fly   253 GISFLSVLVFYLP-SDSGEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTL 316
            .:||:|:|.|.|| :|..|||.|..:||||:..|..:|:|:.|.||..|||||.:......:|.:
 Worm   260 LVSFMSLLAFCLPATDLSEKIGLQTTILLSVCFFLTILSEMTPTTSEAVPLLGVFFSALTFIVAM 324

  Fly   317 SVVVTIAVLNVNFRSPVTHRMAPWVQRLFIQILPKLLCIERPKKEEPEEDQPPEVLTDVYHLPPD 381
            |...||.|||:.:|....|.::|..:.:|::.||.|:.::||.
 Worm   325 STTFTILVLNIRYRQITNHYLSPMFRSIFLECLPWLMMMKRPD---------------------- 367

  Fly   382 VDKFVNYDSKRFSGDYGIPALPASHRFDLAAAGGISAHCFAEPPLPSSLPLPGADD------DLF 440
             .||....|.|.|                  :......|.....|.|.  |.|.|:      :.|
 Worm   368 -HKFRRGSSYRDS------------------SADQCVQCAKNAELKSI--LRGTDNQQQIETNTF 411

  Fly   441 SP-----SGLNGDISPG-----------------------CCPAAA---AAAAADLSPTFEKPYA 474
            .|     ..||..:..|                       .|..:.   .:..|::..|..|.|
 Worm   412 YPFPTETLSLNRKVGDGLFIQRRCQIHEEARSEKFTHGMLACEKSLRENGSELANILVTILKMY- 475

  Fly   475 REMEKTIEGSRFIAQHVKNKDKFESVEEDWKYVAMVLDRMFLWIFAIACVVGTALIILQAPSLYD 539
               |..:.....|.:.:..|.|.:.::::||:.|..:||..|.||.|..:: ...|.:..|
 Worm   476 ---EVMVSQVERIRKRIALKRKRKDIQDEWKFAAQAVDRFCLIIFTIVFII-CCFIFVAIP---- 532

  Fly   540 QSQPIDIL 547
               ||.||
 Worm   533 ---PIKIL 537

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	Neur_chan_LBD	25..240	CDD:280998	95/225 (42%)
		LIC	27..530	CDD:273305	175/551 (32%)
		Neur_chan_memb	247..530	CDD:280999	78/320 (24%)
acr-7	NP_495647.1	LIC	28..524	CDD:273305	176/550 (32%)
		Neur_chan_LBD	31..247	CDD:280998	94/222 (42%)
		Neur_chan_memb	254..524	CDD:280999	78/317 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910