Protein Alignment nAChRalpha1 and unc-29

DIOPT Version :10

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_492399.1
• Gene: unc-29 / 172703
• WormBaseID: WBGene00006765
• Length: 493
• Species: Caenorhabditis elegans
• Alignment Length: 559
• Identity: 220/559 - (39%)
• Similarity: 327/559 - (58%)
• Gaps: 85/559 - (15%)

  Fly     4 VLFAAVFIALHFATGGLANPDAKRLYDDLLSNYNRLIRPVGNNSD-RLTVKMGLRLSQLIDVNLK 67
            :|..:|.|.|.......|:.|.:||..|:...||.||:||.|:|: .|.|||.|:|..||:|:.|
 Worm     9 ILVLSVVIFLVIINTINASDDEERLMVDVFRGYNSLIQPVRNSSELPLIVKMALQLVLLINVDEK 73

  Fly    68 NQIMTTNVWVEQEWNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKAILH 132
            :|:|.||||:..:|:|:::||||.:||.:..:.|..:.:|||||||:|||||||||:.|...:::
 Worm    74 DQVMHTNVWLTLQWHDFQMKWNPVNYGEIKQIRVSPDKVWLPDIVLFNNADGNYEVSFMCNVVIN 138

  Fly   133 HTGKVVWKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEVGIDL 197
            |.|.::|.|||||||.|.||||:||||||.|.:.||||||:...:.|..::...        :|:
 Worm   139 HKGDMLWVPPAIYKSSCIIDVEFFPFDEQVCTLVFGSWTYNENEIKLEFVQAEL--------VDV 195

  Fly   198 QDYYISVEWDIMRVPA-VRNEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSVLV 261
            .:|..|..||::.||| :.|::         ..|.|.:.:|||||||||.||||.|.::|||:.|
 Worm   196 SEYSASSIWDVIDVPASLVNKR---------SRIEFQVRIRRKTLFYTVVLIIPTVLMAFLSMAV 251

  Fly   262 FYLPSDSGEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAVLN 326
            |:||:||||||:|.||:|||:.||.||:::|:||||.|:||:.||||.|.:|..::::||:.::|
 Worm   252 FFLPTDSGEKITLTISVLLSIVVFLLLVSKILPPTSSTIPLMAKYLLLTFVLNVITILVTVIIIN 316

  Fly   327 VNFRSPVTHRMAPWVQRLFIQILPKLLCIERPKKEEPEEDQPPEVLTDVYHLPPDVDKFVNYDSK 391
            |.||.|.||||..||:.:|:|.||||:|::|||..                            |:
 Worm   317 VYFRGPRTHRMPQWVRVVFLQFLPKLVCMKRPKSA----------------------------SE 353

  Fly   392 RFSGDYGIPALPASHRFDLAAAGGISAHCFAEPPLPSSLPLPGADDDLFSPSGLNGDISPGCCPA 456
            |.:...|:..||...:|.|:.    |||    .||     .|.|||.               ...
 Worm   354 RSAVRSGMAQLPGVGQFTLSP----SAH----HPL-----CPSADDR---------------TTT 390

  Fly   457 AAAAAAADLSPTFEKPYAREMEKTIEGSRFIAQHVKNKDKFESVEEDWKYVAMVLDRMFLWIFAI 521
            ....|:.:.|..:  |.:.:..:.|:...:|.:|:|..::.:|..:|||||||::||:.|::|..
 Worm   391 IRNTASNETSAYY--PLSTDALRAIDAIEYITEHLKRDEQHKSFRDDWKYVAMIIDRLLLYVFFG 453

  Fly   522 ACVVGTALIILQAPSLY---DQSQPIDILYSKIAKKKFE 557
            ..|.||..|:..||.::   ||.:.:|.|     |:|::
 Worm   454 ITVGGTCGILFSAPHVFQRIDQQEMLDRL-----KEKYD 487

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	LGIC_ECD_nAChR_proto_alpha-like	24..242	CDD:349832	98/219 (45%)
		LIC	27..530	CDD:455710	205/504 (41%)
		Cys-loop	149..163	CDD:349832	11/13 (85%)
unc-29	NP_492399.1	LIC	6..466	CDD:455710	212/531 (40%)
		LGIC_ECD_nAChR_proto_beta-like	29..230	CDD:349833	96/217 (44%)
		Cys-loop	155..169	CDD:349833	11/13 (85%)