Protein Alignment nAChRalpha1 and unc-63

DIOPT Version :10

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_491533.2
• Gene: unc-63 / 172150
• WormBaseID: WBGene00006797
• Length: 502
• Species: Caenorhabditis elegans
• Alignment Length: 553
• Identity: 277/553 - (50%)
• Similarity: 356/553 - (64%)
• Gaps: 79/553 - (14%)

  Fly     6 FAAVFIALHFATGGLANPDAKRLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLKNQI 70
            ||.:.|.|..:....||.||.||::||:::||:|:|||..|.:.|.|...|:||||:||:.||||
 Worm     8 FAYILIFLLLSPPTHANRDANRLFEDLIADYNKLVRPVSENGETLVVTFKLKLSQLLDVHEKNQI 72

  Fly    71 MTTNVWVEQEWNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKAILHHTG 135
            ||||||::..|.||||:|:|.:||||:.|:|||:.|||||:||||||||||:|||||||.|.:.|
 Worm    73 MTTNVWLQHSWMDYKLRWDPVEYGGVEVLYVPSDTIWLPDVVLYNNADGNYQVTIMTKAKLTYNG 137

  Fly   136 KVVWKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDL----RHLKQTADSD------- 189
            .|.|.|||||||.|:||||:||||.|.|.||||||||.|..|||    :||::..:.|
 Worm   138 TVEWAPPAIYKSMCQIDVEFFPFDRQQCEMKFGSWTYGGLEVDLQHRDKHLEKEIEEDVEGVDGP 202

  Fly   190 ------NIEVGIDLQDYYISVEWDIMRVPAVRNEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNLI 248
                  .::.||||.|||.||||||:.||..|:.|.|.|||.|::||.:.:.|||||||||||||
 Worm   203 TKEIVWVVDRGIDLSDYYPSVEWDILNVPGKRHSKRYPCCESPFIDITYEIHLRRKTLFYTVNLI 267

  Fly   249 IPCVGISFLSVLVFYLPSDSGEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMML 313
            .|.||||||:.||||||||.|||||||||||:|||||||||.||||.|||.:||:||||||||:|
 Worm   268 FPSVGISFLTALVFYLPSDGGEKISLCISILISLTVFFLLLVEIIPSTSLVIPLIGKYLLFTMVL 332

  Fly   314 VTLSVVVTIAVLNVNFRSPVTHRMAPWVQRLFIQILPKLLCIERPKKEEPEEDQPPEVLTDVYHL 378
            ||||||||:..|||::|||.||.|..|::|||:..|||.|.:.||        |||.     :|.
 Worm   333 VTLSVVVTVVTLNVHYRSPTTHTMPKWMKRLFVDFLPKYLLMTRP--------QPPG-----HHS 384

  Fly   379 PPDVDKFVNYDSKRFSGDYGIPALPASHRFDLAAAGGISAHCFAEPPLPSSLPLPGADDDLFSPS 443
            .|:    ..:||:..:...|:     :|                         :.|.:.:|.||
 Worm   385 KPN----RKFDSRASTFSIGV-----NH-------------------------VLGQNSELLSP- 414

  Fly   444 GLNGDISPGCCPAAAAAAAADLSPTFEKPYAREMEKTIEGSRFIAQHVKNKDKFESVEEDWKYVA 508
            |||.:..     .::.....|.||         :...:|...:||.|:||::..:.|.|||||::
 Worm   415 GLNSNRE-----ESSFTLPRDNSP---------VRSAVESVAYIADHLKNEEDDKQVIEDWKYIS 465

  Fly   509 MVLDRMFLWIFAIACVVGTALIILQAPSLYDQS 541
            :|:||:||..|..||..||.:||.:|||:||.:
 Worm   466 VVMDRIFLITFTFACAFGTVVIIARAPSIYDNT 498

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	LGIC_ECD_nAChR_proto_alpha-like	24..242	CDD:349832	135/234 (58%)
		LIC	27..530	CDD:455710	262/519 (50%)
		Cys-loop	149..163	CDD:349832	10/13 (77%)
unc-63	NP_491533.2	LIC	6..487	CDD:455710	270/540 (50%)
		LGIC_ECD_nAChR_proto_alpha-like	26..261	CDD:349832	135/234 (58%)
		Cys-loop	151..165	CDD:349832	10/13 (77%)