DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nAChRalpha1 and HTR3C

DIOPT Version :9

Sequence 1:	NP_001262916.1	Gene:	nAChRalpha1 / 42918	FlyBaseID:	FBgn0000036	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	NP_570126.2	Gene:	HTR3C / 170572	HGNCID:	24003	Length:	447	Species:	Homo sapiens

Alignment Length:	337	Identity:	89/337 - (26%)
Similarity:	166/337 - (49%)	Gaps:	35/337 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 RLIRPVGNNSDRLTVKMGLRLSQLIDVNLKNQIMTTNVWVEQEWNDYKLKWNPDDYGGVDTLHVP 102
            :..||..|.|....|.:...||.::.|:.:.|::|:.:|::..|::..:.|||.:..|::.|.|.
Human    52 KAFRPFTNYSIPTRVNISFTLSAILGVDAQLQLLTSFLWMDLVWDNPFINWNPKECVGINKLTVL 116

  Fly   103 SEHIWLPDIVLYNNADGNYEVTIMTKAILHHTGKVVWKPPAIYKSFCEIDVEYFPFDEQTCFMKF 167
            :|::|||||.:..:.|.:...:.:| |.:...|::.:..|....|.|.:|:.|||||:|.|...|
Human   117 AENLWLPDIFIVESMDVDQTPSGLT-AYISSEGRIKYDKPMRVTSICNLDIFYFPFDQQNCTFTF 180

  Fly   168 GSWTYDGYMVDLRHLKQTADSDNIEVGIDLQDYYIS----------VEWDIMRVPAVRNEKFYSC 222
            .|:.|            |.||  :.:|:|.:.:.|:          .||:::.:.....:  .|.
Human   181 SSFLY------------TVDS--MLLGMDKEVWEITDTSRKVIQTQGEWELLGINKATPK--MSM 229

  Fly   223 CEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSVLVFYLPSDSGEKISLCISILLSLTVFFL 287
            ....|..|:|.:.:||:...|.:||::|...:..:..|.||||::|..:....|::||...||.|
Human   230 GNNLYDQIMFYVAIRRRPSLYIINLLVPSSFLVAIDALSFYLPAESENRAPFKITLLLGYNVFLL 294

  Fly   288 LLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAV---LNVNFRSPVTHRMAPWVQRLFIQIL 349
            ::.:::|.:.  .||:..|....:.|:.:|::.|:.:   |:|....|..  |..|:..|.:...
Human   295 MMNDLLPASG--TPLISVYFALCLSLMVVSLLETVFITYLLHVATTQPPP--MPRWLHSLLLHCT 355

  Fly   350 -PKLLCIERPKK 360
             |...|...|:|
Human   356 SPGRCCPTAPQK 367

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	Neur_chan_LBD	25..240	CDD:280998	56/211 (27%)
		LIC	27..530	CDD:273305	89/337 (26%)
		Neur_chan_memb	247..530	CDD:280999	31/118 (26%)
HTR3C	NP_570126.2	Neur_chan_LBD	43..445	CDD:332142	89/337 (26%)
HTR3C	NP_570126.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	380..405
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810