Protein Alignment nAChRalpha1 and CHRNG

DIOPT Version :10

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_005190.4
• Gene: CHRNG / 1146
• HGNCID: 1967
• Length: 517
• Species: Homo sapiens
• Alignment Length: 554
• Identity: 182/554 - (32%)
• Similarity: 268/554 - (48%)
• Gaps: 96/554 - (17%)

  Fly     9 VFIALHFATGGLANPDAKRLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLKNQIMTT 73
            :.:.|....|.......:||..||:.||:..:||...:||.:.|.:.|.|:.||.:|.:.:.:||
Human    10 LLLLLAVCLGAQGRNQEERLLADLMQNYDPNLRPAERDSDVVNVSLKLTLTNLISLNEREEALTT 74

  Fly    74 NVWVEQEWNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKAILHHTGKVV 138
            |||:|.:|.||:|:|:|.||.|:..|.|||..:|.|||||.||.||.:||.:....::...|.:.
Human    75 NVWIEMQWCDYRLRWDPRDYEGLWVLRVPSTMVWRPDIVLENNVDGVFEVALYCNVLVSPDGCIY 139

  Fly   139 WKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIE-VGIDLQDYYI 202
            |.||||::|.|.|.|.|||||.|.|.:.|.|.||....:||: |.| .|...|| :.||.:.:..
Human   140 WLPPAIFRSACSISVTYFPFDWQNCSLIFQSQTYSTNEIDLQ-LSQ-EDGQTIEWIFIDPEAFTE 202

  Fly   203 SVEWDIMRVPA-VRNEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSVLVFYLPS 266
            :.||.|...|| :..:......|..:..:||.|.::||.|||.:|:|.|||.||.:::|:.:||:
Human   203 NGEWAIQHRPAKMLLDPAAPAQEAGHQKVVFYLLIQRKPLFYVINIIAPCVLISSVAILIHFLPA 267

  Fly   267 DS-GEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAVLNVNFR 330
            .: |:|.::.|::||:.|||..|:|:.:|.||..|||:.|||.|.:::..|.||..:.||||:.|
Human   268 KAGGQKCTVAINVLLAQTVFLFLVAKKVPETSQAVPLISKYLTFLLVVTILIVVNAVVVLNVSLR 332

  Fly   331 SPVTHRMAPWVQRLFIQILPKLLCIE-RPKKEEPEEDQPPEVLTDVYHLPP----DVDKFVNYDS 390
            ||.||.||..|:::|:::||:||.:. ||                   |.|    |....:...|
Human   333 SPHTHSMARGVRKVFLRLLPQLLRMHVRP-------------------LAPAAVQDTQSRLQNGS 378

  Fly   391 KRFS---GDYGIPALPAS-------HRFDLAAAG----------GISAHCFAEPPLPSSLPLPGA 435
            ..:|   |:.....||.|       .|..|.||.          |:|..|
Human   379 SGWSITTGEEVALCLPRSELLFQQWQRQGLVAAALEKLEKGPELGLSQFC--------------- 428

  Fly   436 DDDLFSPSGLNGDISPGCCPAAAAAAAADLSPTFEKPYAREMEKTIEGSRFIAQHVKNKDKFESV 500
                            |....||.|                ::..:|....||.....:..|::.
Human   429 ----------------GSLKQAAPA----------------IQACVEACNLIACARHQQSHFDNG 461

  Fly   501 EEDWKYVAMVLDRMFLWIFAIACVVGTALIILQA 534
            .|:|..|..||||:.........:.|||.|.|.|
Human   462 NEEWFLVGRVLDRVCFLAMLSLFICGTAGIFLMA 495

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	LGIC_ECD_nAChR_proto_alpha-like	24..242	CDD:349832	88/219 (40%)
		LIC	27..530	CDD:455710	177/530 (33%)
		Cys-loop	149..163	CDD:349832	9/13 (69%)
CHRNG	NP_005190.4	LGIC_ECD_nAChR_G	49..241	CDD:349830	78/193 (40%)
		Cys-loop	150..164	CDD:349830	9/13 (69%)
		Neur_chan_memb	248..492	CDD:460753	85/309 (28%)