DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRalpha1 and CHRNE

DIOPT Version :9

Sequence 1:NP_001262916.1 Gene:nAChRalpha1 / 42918 FlyBaseID:FBgn0000036 Length:597 Species:Drosophila melanogaster
Sequence 2:NP_000071.1 Gene:CHRNE / 1145 HGNCID:1966 Length:493 Species:Homo sapiens


Alignment Length:533 Identity:171/533 - (32%)
Similarity:269/533 - (50%) Gaps:70/533 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 VFIALHFATGGLANPDAKRLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLKNQIMTT 73
            |.:.|.....|:...:..|||..|.:||:...|||....|.:|:.:.:.|:.||.:|.|.:.:||
Human     8 VLLLLGLLGRGVGKNEELRLYHHLFNNYDPGSRPVREPEDTVTISLKVTLTNLISLNEKEETLTT 72

  Fly    74 NVWVEQEWNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKAILHHTGKVV 138
            :||:..:|.||:|.::.||:||::||.||||.:|||:|||.||.||.:.|......:::..|.|.
Human    73 SVWIGIDWQDYRLNYSKDDFGGIETLRVPSELVWLPEIVLENNIDGQFGVAYDANVLVYEGGSVT 137

  Fly   139 WKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDN---IEVGIDLQDY 200
            |.|||||:|.|.::|.|||||.|.|.:.|.|.||:...|:...   ..|:|.   .::.||.:.|
Human   138 WLPPAIYRSVCAVEVTYFPFDWQNCSLIFRSQTYNAEEVEFTF---AVDNDGKTINKIDIDTEAY 199

  Fly   201 YISVEWDIMRVPAVRNEKFYSCCEEP-YLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSVLVFYL 264
            ..:.||.|...|.|.........:.| ..|::::|.:|||.|||.:|:|:|||.||.|.:|.::|
Human   200 TENGEWAIDFCPGVIRRHHGGATDGPGETDVIYSLIIRRKPLFYVINIIVPCVLISGLVLLAYFL 264

  Fly   265 PSDS-GEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAVLNVN 328
            |:.: |:|.::.|::||:.|||..|:|:.||.|||:|||||::|:|.|::.||.|:..:.||||:
Human   265 PAQAGGQKCTVSINVLLAQTVFLFLIAQKIPETSLSVPLLGRFLIFVMVVATLIVMNCVIVLNVS 329

  Fly   329 FRSPVTHRMAPWVQRLFIQILPKLLCIERPKKEEPEEDQPPEVLTDVYHLPPDVDKFVNYDSKR- 392
            .|:|.||.|:|.::.:.:::||:||. ..|..|.|....||...:.|..|....:..:...... 
Human   330 QRTPTTHAMSPRLRHVLLELLPRLLG-SPPPPEAPRAASPPRRASSVGLLLRAEELILKKPRSEL 393

  Fly   393 -FSGDYGIPALPASHRFDLAAAGGISAHCFAEPPLPSSLPLPGADDDLFSPSGLNGDISPGCCPA 456
             |.|.        .||                                      .|..:...|.:
Human   394 VFEGQ--------RHR--------------------------------------QGTWTAAFCQS 412

  Fly   457 AAAAAAADLSPTFEKPYAREMEKTIEGSRFIAQHVKNKDKFESVEEDWKYVAMVLDRMFLWIFAI 521
            ..|||.             |:...::...|:|:..::::.......||..:...||.:..|...:
Human   413 LGAAAP-------------EVRCCVDAVNFVAESTRDQEATGEEVSDWVRMGNALDNICFWAALV 464

  Fly   522 ACVVGTALIILQA 534
            ...||::||.|.|
Human   465 LFSVGSSLIFLGA 477

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha1NP_001262916.1 Neur_chan_LBD 25..240 CDD:280998 83/218 (38%)
LIC 27..530 CDD:273305 164/509 (32%)
Neur_chan_memb 247..530 CDD:280999 76/285 (27%)
CHRNENP_000071.1 LIC 21..475 CDD:273305 166/516 (32%)
Neur_chan_LBD 24..240 CDD:280998 83/218 (38%)
Neur_chan_memb 247..474 CDD:280999 77/286 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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